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Quantitative Volumetric Analysis of Progressive Hemifacial Atrophy Corrected Using Stromal Vascular Fraction–Supplemented Autologous Fat Grafts


  • Qiang Chang and Feng Lu contributed equally to the research and should be regarded as co-first authors.
  • The authors have indicated no significant interest with commercial supporters.

Address correspondence and reprint requests to: Feng Lu, Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou North Road, 1838 Guangzhou, Guangdong 510515, China, or e-mail:



Progressive hemifacial atrophy (Parry-Romberg disease) is rare and involves all skin layers and subcutaneous soft and hard tissue. Autologous fat grafting has revolutionized the field of soft-tissue reconstruction and augmentation, but long-term maintenance is unpredictable. Stromal vascular fraction (SVF)-supplemented cell therapy offers new hope for improving fat graft survival, with good long-term results, but efficacy and long-term outcome in the clinic are rarely studied using objective data.


To compare the long-term viability of SVF-supplemented fat grafts and fat grafts alone for contour reconstruction of progressive hemifacial atrophy using quantitative volume analysis.


We treated 20 patients with stable hemifacial atrophy for at least 2 years with SVF-supplemented autologous fat grafting (n = 10) or fat grafting alone (n = 10). All patients were followed up every 3 months. Hemifacial volume was measured using computed tomography and the Philips Extended Brilliance Workspace.


All patients had successful outcomes without complications, but fat survival and clinical improvement was greater with SVF-supplemented grafting than fat grafting alone after 6 months.


SVF-supplemented autologous fat transplantation is effective and safe for treating progressive hemifacial atrophy and can enhance the survival of grafts in the face without major complications.