Many remedies can be applied to condyloma acuminatum. However, it is the most difficult to treat giant condyloma acuminatum because of bleeding, recurrence, intolerance of patients, etc. After careful physical examination, the present authors found the giant tumor was composed of many smaller cauliflower-like warts with long and thin pedicles. So the present authors successfully excised the giant tumor mainly by clamping and cutting the pedicles with the best effects, the least damage to the perineal and perianal areas and lower recurrence. After 2 months, the patient recovered very well and remained free of recurrence at a 2-year follow-up.