Understanding the pathophysiology of itch


Address correspondence and reprint requests to: Ethan A. Lerner, MD, PhD, Dermatology/Cutaneous Biology Research Center, Massachusetts General Hospital, Bldg. 149, 13th Street, Charlestown, MA 02129, USA, or email: elerner@partners.org.


Itch is the most common symptom described by our patients. Treating this symptom can be challenging. A revolution is ongoing in understanding the pathophysiology of itch and will allow this challenge to be met. The present authors review and update the current understanding of the pathophysiology of itch.