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Efficacy of treatment with oral alitretinoin in patient suffering from lichen simplex chronicus and severe atopic dermatitis of hands

Authors

  • Angelo Massimiliano D'Erme,

    Corresponding author
    1. Allergological and Occupational Dermatology Unit, Department of Surgery and Translational Medicine, University of Florence, Florence
    • Address correspondence and reprint requests to: Angelo Massimiliano D'Erme, MD, Allergological and Occupational Dermatology Unit, Department of Surgery and Translational Medicine, University of Florence, Piazza dell'Indipendenza 11, 50129 Florence, Italy, or email: a.m.derme@gmail.com.

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  • Nicola Milanesi,

    1. Allergological and Occupational Dermatology Unit, Department of Surgery and Translational Medicine, University of Florence, Florence
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  • Arianna Fay Agnoletti,

    1. DISSAL Section of Dermatology San Martino-IRCCS, Genoa, Italy
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  • Vincenza Maio,

    1. Division of Pathological Anatomy, Department of Critical Care Medicine and Surgery, University of Florence, Florence, Italy
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  • Daniela Massi,

    1. Division of Pathological Anatomy, Department of Critical Care Medicine and Surgery, University of Florence, Florence, Italy
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  • Massimo Gola

    1. Allergological and Occupational Dermatology Unit, Department of Surgery and Translational Medicine, University of Florence, Florence
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  • Learning Points: Alitretinoin can represent an effective drug for the treatment of lichen simplex chronicus and atopic dermatitis of hands.
  • The authors declare no affiliation or significant financial involvement in any organization or entity with a direct financial interest in the subject matter or materials discussed in the following manuscript.

Abstract

Lichen simplex chronicus (LSC) is a skin disorder characterized by chronic itching and scratching, which can lead to thick, leathery, brownish skin, sometimes with papules and can be associated with atopic eczema. We report the case of a 52-year-old man with a 45-year atopic condition and presenting LSC in his dorsum. After a 3-month treatment with alitretinoin at the daily dosage of 30 mg, we have observed a moderate improvement of the hand eczema together with a substantial clinical improvement of LSC and an almost complete resolution of pruritus. We want to report this peculiar case to suggest the use of oral alitretinoin for LSC.

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