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Hyperbaric oxygen for chronic wounds

Authors

  • Lee J. Goldstein

    Corresponding author
    • Division of Vascular and Endovascular Surgery, DeWitt Daughtry Family Department of Surgery, University of Miami, Miami, Florida
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Address correspondence and reprint requests to: Lee J. Goldstein, MD, FACS, CWS, Assistant Professor of Vascular Surgery, Division of Vascular and Endovascular Surgery, DeWitt Daughtry Family Department of Surgery, Holtz Building (Suite 3016), 1611 NW 12th Avenue, Miami, FL 33169, or email: lgoldstein@med.miami.edu.

Abstract

Hyperbaric oxygen therapy (HBOT), the administration of pressurized 100% oxygen, is used as an adjunct to aid healing in selected chronic wounds. Though the therapy has had a controversial history, research is now elucidating the mechanisms by which HBOT helps to heal wounds. HBOT increases growth factors and local wound signaling, while also promoting a central stem cell release of endothelial progenitor cells from the bone marrow via nitric oxide pathways. The clinical data continue to accumulate in support of HBOT to help hasten wound healing, and reduce the amputation rate in diabetic ulcers. In appropriate patients, HBOT is an effective, noninvasive, adjunct modality that can be used to hasten chronic wound healing.

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