Conflicts of Interest: Ms. Wong, Dr. Heller, Dr. Eliason, and Dr. Murase have no conflicts of interest to disclose. There was no funding provided for the production of this article.
Dermatological medication effects on male fertility
Article first published online: 5 AUG 2013
© 2013 Wiley Periodicals, Inc.
Special Issue: Treatment of Cutaneous Disorders of Pregnancy
Volume 26, Issue 4, pages 337–346, July/August 2013
How to Cite
Millsop, J. W., Heller, M. M., Eliason, M. J. and Murase, J. E. (2013), Dermatological medication effects on male fertility. Dermatologic Therapy, 26: 337–346. doi: 10.1111/dth.12069
- Issue published online: 5 AUG 2013
- Article first published online: 5 AUG 2013
- dermatologic therapy;
- dermatological medication;
- male infertility;
Many drugs have been reported to impair semen parameters, leading to temporary or persistent infertility. Therefore, potential fathers may be concerned about the effect of medications on fertility. We searched the MEDLINE database of articles in English combining key terms including “male infertility,” “spermatogenesis,” “fertility,” “drug effects,” and “dermatology.” Administration of methotrexate and finasteride has resulted in severe oligospermia and reversible infertility. Ketoconazole has had negative effects on sperm motility and testosterone production. Few individual case reports and a limited number of studies have demonstrated negative effects of tetracyclines, erythromycin, chloroquine, glucocorticoids, spironolactone, and antihistamines on fertility. It is important to counsel male patients when appropriate about the reversible negative effect on fertility when taking methotrexate and finasteride, and the adverse effect of ketoconazole. Patients may be reassured that taking oral retinoids, cyclosporine, azathioprine, and tumor necrosis factor alpha inhibitors should not affect their fertility.