Financial Disclosure Statement: The authors have no financial relationships relevant to this article to disclose.
Urticaria mimickers in children
Article first published online: 9 DEC 2013
© 2013 Wiley Periodicals, Inc.
Special Issue: Update on Pediatric Dermatology
Volume 26, Issue 6, pages 467–475, November/December 2013
How to Cite
Mathur, A. N. and Mathes, E. F. (2013), Urticaria mimickers in children. Dermatologic Therapy, 26: 467–475. doi: 10.1111/dth.12103
Conflict of Interest Statement: The authors have no conflicts of interest to disclose.
- Issue published online: 9 DEC 2013
- Article first published online: 9 DEC 2013
- acute hemorrhagic edema of infancy;
- cryopyrin-related disorders;
- serum-sickness-like reaction;
- systemic onset juvenile idiopathic arthritis;
- urticaria multiforme
Acute urticaria is a self-limited cutaneous condition marked by transient, erythematous, and pruritic wheals. It is a hypersensitivity response that is often secondary to infection, medications, or food allergies in children. In contrast, the urticarial “mimickers” described in this review article are often seen in the context of fever and extracutaneous manifestations in pediatric patients. The differential diagnosis ranges from benign and self-limited hypersensitivity responses to multisystem inflammatory diseases. Establishing the correct diagnosis of an urticarial rash in a pediatric patient is necessary to both prevent an unnecessary work up for self-limited conditions and to appropriately recognize and evaluate multisystem inflammatory disorders. Herein, we describe two cases to illustrate the clinical manifestations, laboratory findings, histopathology and differential diagnoses for several mimickers of acute urticaria including: urticaria multiforme, serum sickness like reaction, Henoch-Schönlein purpura, acute hemorrhagic edema of infancy, systemic onset juvenile idiopathic arthritis, cryopyrin associated periodic syndromes, and urticarial vasculitis.