Management of a pemphigus with IgA and IgG antibodies and coexistent lung cancer
Article first published online: 22 APR 2014
© 2014 Wiley Periodicals, Inc.
Volume 27, Issue 4, pages 236–239, July/August 2014
How to Cite
Cetkovská, P., Komorousová, M. and Lomicová, I. (2014), Management of a pemphigus with IgA and IgG antibodies and coexistent lung cancer. Dermatologic Therapy, 27: 236–239. doi: 10.1111/dth.12126
- Issue published online: 25 JUL 2014
- Article first published online: 22 APR 2014
- IgA/IgG pemphigus;
- lung cancer
Immunoglobulin A (IgA) pemphigus is a clinically distinct variant of pemphigus characterized by intercellular IgA deposition in the epidermis. Recently, an IgA/Immunoglobulin G (IgG) subset of pemphigus with IgA and IgG anti-keratinocyte cell surface antibodies has been described. Both IgA and IgA/IgG pemphigus have been associated with internal malignancies. Above all, monoclonal IgA gammopathy in patients with IgA pemphigus has been reported, and lung cancers in association with IgA/IgG pemphigus have been described. IgA pemphigus can be successfully treated with dapsone, whereas therapeutic management of IgG/IgA pemphigus is not well established yet. We report a rare case of a patient, who developed atypical pemphigus with both IgA and IgG autoantibodies and an underlying lung cancer, successfully treated with corticosteroids and dapsone.