Evaluation of TNF-α serum level in patients with recalcitrant multiple common warts, treated by lipid garlic extract

Authors

  • Soha Kenawy,

    1. Department of Dermatology and Venereology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
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  • Ghada Farouk Mohammed,

    Corresponding author
    1. Department of Dermatology and Venereology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
    • Address correspondence and reprint requests to: Ghada Farouk Abd El-Kaream Mohammed, MD, Department of Dermatology and Venereology, Faculty of Medicine, Suez Canal University, Ismailia 41511, Egypt, or email: Dr_Ghada77@hotmail.com.

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  • Soha Younes,

    1. Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
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  • Atef Ibrahim Elakhras

    1. Department of Dermatology and Venereology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
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Abstract

No universal consensus about optimal modality for treating the recalcitrant multiple common warts (RMCW). The objective of the study was to evaluate the immunological mechanisms and clinical therapeutic effect of using lipid garlic extract (LGE) in the treatment of RMCW. The study included 50 patients with RMCW. They were randomly assigned into two groups: the first group (25 patients) received LGE, and the second group (25 patients) received saline as a control group. In both groups, treatments were made to single lesions, or largest wart in case of multiple lesions, until complete clearance of lesions or for a maximum of 4 weeks. Blood serum was taken at pre-study and at the fourth week to measure tumor necrosis factor alpha (TNF-α) level. A significant difference was found between the therapeutic responses of RMCW to LGE antigen and saline control group (p < 0.001). In the LGE group, complete response was achieved in 96% of patients presenting with RMCW. There was a statistically nonsignificant increase in TNF-α of LGE group versus saline group. No recurrence was observed in the LGE group. LGE as an immunotherapy is an inexpensive, effective, and safe modality with good cure rates for treatment of RMCWs, when other topical or physical therapies have failed.

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