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Five-year follow-up of survival and relapse in patients who received cryotherapy during high-dose chemotherapy for stem cell transplantation shows no safety concerns

Authors

  • A. SVANBERG MSC, RN,

    Corresponding author
    1. Institute for Medical Sciences, Faculty of Medicine, Uppsala University, Uppsala, Sweden
      Anncarin Svanberg, Department of Haematology 50 C, Akademiska Hospital, SE – 751 85 Uppsala, Sweden (e-mail: ann-carin.svanberg@akademiska.se).
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  • K. ÖHRN PHD, RDH,

    1. School of Health and Social Sciences, Dalarna University, Falun
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  • G. BIRGEGÅRD MD, PHD, PROFESSOR

    1. Institute for Medical Sciences, Faculty of Medicine, Uppsala University, Uppsala, Sweden
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Anncarin Svanberg, Department of Haematology 50 C, Akademiska Hospital, SE – 751 85 Uppsala, Sweden (e-mail: ann-carin.svanberg@akademiska.se).

Abstract

SVANBERG A., ÖHRN K. & BIRGEGÅRD G. (2012) European Journal of Cancer Care

Five-year follow-up of survival and relapse in patients who received cryotherapy during high-dose chemotherapy for stem cell transplantation shows no safety concerns

We have previously published a randomised controlled study of the efficacy of cryotherapy in preventing acute oral mucositis after high-dose chemotherapy for stem cell transplantation. The present study is a 5-year follow-up safety study of survival in these patients. In the previously published study oral cryotherapy (cooling of the oral cavity) during high-dose chemotherapy significantly reduced mucositis grade and opiate use in the treated group. All patients were followed up for at least 5 years with regard to relapse and death rates. Baseline data, transplant complications and mucositis data were compared. Significantly more patients (25/39) who received oral cryotherapy were alive after 5 years compared to 15/39 in the control group (P= 0.025). Relapse rates were similar. The only baseline difference was a lower proportion of patients in complete remission at transplantation in the control group (6 vs. 13, P= 0.047). This 5-year follow-up study gave no support for safety concerns with cryotherapy.

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