Members of the email@example.com study group are present in Appendix.
Factors determining high-sensitivity C-reactive protein values in the Spanish population. Di@bet.es study
Article first published online: 7 NOV 2012
© 2012 The Authors. European Journal of Clinical Investigation © 2012 Stichting European Society for Clinical Investigation Journal Foundation
European Journal of Clinical Investigation
Volume 43, Issue 1, pages 1–10, January 2013
How to Cite
Rojo-Martínez, G., Soriguer, F., Colomo, N., Calle, A., Goday, A., Bordiú, E., Delgado, E., Menéndez, E., Ortega, E., Urrutia, I., Girbés, J., Castaño, L., Catalá, M., Gaztambide, S., Valdés, S. and On behalf of the firstname.lastname@example.org study group (2013), Factors determining high-sensitivity C-reactive protein values in the Spanish population. Di@bet.es study. European Journal of Clinical Investigation, 43: 1–10. doi: 10.1111/eci.12002
- Issue published online: 20 DEC 2012
- Article first published online: 7 NOV 2012
- Accepted manuscript online: 1 SEP 2012 12:19AM EST
- Received 15 May 2012; accepted 29 August 2012
- High-sensitivity C-reactive protein;
- population values;
- cardiovascular risk factors
Eur J Clin Invest 2012
Background Although high-sensitivity C-reactive protein (hs-CRP) is currently used as a risk marker of cardiovascular disease, it has been suggested that genetic, clinical, biochemical or environmental factors could modify hs-CRP levels. The aim of this study was to investigate sources of interindividual hs-CRP variability in the Spanish population.
Materials and methods A representative sample of the Spanish population within the email@example.com study was used. Study variables included a clinical and demographic structured survey, a lifestyle survey, a physical examination, plasmatic hs-CRP and other biochemical parameters.
Results Median and interquartile range of plasma hs-CRP values were 1·73 ± 2·75 mg/dL. Thirty per cent of the study population had hs-CRP levels above 3 mg/dL and 38% from 1 to 3 mg/dL. Body mass index was the strongest factor associated with moderate and high hs-CRP levels. Age, sex, waist-to-hip ratio, weight increase, plasma lipid levels, glucose metabolism (HOMA-IR and abnormal glucose regulation categories), pharmacological treatment (lipid-lowering agents, psychotropic drugs and levothyroxine), smoking, physical activity, different dietary patterns, quality of life and educational level were all significantly associated with hs-CRP levels. Interactions were observed between variables. These interactions modulated the effect of previously described factors on hs-CRP.
Conclusions Thirty per cent of the Spanish population have hs-CRP levels considered to represent a cardiovascular risk. Different clinical, anthropometric, biochemical and environmental variables modulate hs-CRP levels. In addition, multiple interactions between variables complicate the interpretation of hs-CRP values.