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C-reactive protein and incidence of type 2 diabetes in the Pizarra study

Authors

  • Elehazara Rubio-Martín,

    Corresponding author
    1. Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Málaga, Spain
    2. Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain
    • Department of Endocrinology and Nutrition, Hospital Universitario Carlos Haya, Málaga, Spain
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  • Federico Soriguer,

    1. Department of Endocrinology and Nutrition, Hospital Universitario Carlos Haya, Málaga, Spain
    2. Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Málaga, Spain
    3. Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain
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  • Carolina Gutiérrez-Repiso,

    1. Department of Endocrinology and Nutrition, Hospital Universitario Carlos Haya, Málaga, Spain
    2. Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Málaga, Spain
    3. Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain
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  • Lourdes Garrido-Sánchez,

    1. Department of Endocrinology and Nutrition, Hospital Universitario Carlos Haya, Málaga, Spain
    2. Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Málaga, Spain
    3. Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain
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  • Marisol S. Ruíz de Adana,

    1. Department of Endocrinology and Nutrition, Hospital Universitario Carlos Haya, Málaga, Spain
    2. Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Málaga, Spain
    3. Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain
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  • Eduardo García-Fuentes,

    1. Department of Endocrinology and Nutrition, Hospital Universitario Carlos Haya, Málaga, Spain
    2. Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Málaga, Spain
    3. Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain
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  • Sonsoles Morcillo,

    1. Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Málaga, Spain
    2. Endocrinology and Diabetes Research Group, Hospital de Cruces and University of the Basque Country UPV-EHU, Barakaldo, Spain
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  • Isabel Esteva,

    1. Department of Endocrinology and Nutrition, Hospital Universitario Carlos Haya, Málaga, Spain
    2. Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Málaga, Spain
    3. Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain
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  • Felipe J Chaves,

    1. Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Málaga, Spain
    2. Genotyping and Genetic Diagnosis Unit, Fundación de Investigación del Hospital Clínico de Valencia INCLIVA, Valencia, Spain
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  • Gemma Rojo-Martinez

    1. Department of Endocrinology and Nutrition, Hospital Universitario Carlos Haya, Málaga, Spain
    2. Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Málaga, Spain
    3. Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain
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Correspondence to: Elehazara Rubio-Martín, Hospital Civil (Hospital Regional Universitario Carlos Haya), Plaza del Hospital Civil s/n, Servicio de Endocrinología y Nutrición, Laboratorio de Investigación, Pabellón 5 sótano, 29009 Malaga, Spain. Tel.: +34 951030343; fax: +34 952286704; e-mail: elehazara@gmail.com

Abstract

Aim

To determine the association between serum levels of high-sensitivity C-reactive protein (hs-CRP) and the incidence of type 2 diabetes in a prospective cohort from southern Spain (Pizarra study).

Materials and methods

The study formed part of the Pizarra cohort study, a prospective study started in 1995 with a follow-up of 11 years. Anthropometric and metabolic variables were measured at baseline and at 6 years and 11 years of follow-up. All subjects underwent an oral glucose tolerance test. Serum levels of TNFα and its receptors, hs-CRP, IL-6, leptin, adiponectin and FABP4 were measured at 6 years of follow-up.

Results

After adjusting for age, sex and obesity, subjects with levels of hs-CRP> 2.9 mg/L in the second study (2003–4) had a higher risk of developing type 2 diabetes by the third study (2008–9) (OR = 7.97; 95% CI = 1.72–36.89; P = 0.008), and subjects with adiponectin levels > 13.2 mg/L had a lower risk of developing type 2 diabetes (OR = 0.23, P = 0.02). High values of hs-CRP and high values of adiponectin were associated positively (OR = 8.26; 95% CI = 1.84–37.19; P = 0.006) and negatively (OR = 0.17; 95% CI = 0.04–0.69; P = 0.01), respectively, with the risk of having HbA1c ≥ 6.5% at 11 years of follow-up.

Conclusions

Subjects with high serum hs-CRP levels and low serum adiponectin levels have a higher risk of developing type 2 diabetes within five years.

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