Memory-guided saccades in youth-onset psychosis and attention deficit hyperactivity disorder (ADHD)
Article first published online: 28 FEB 2013
© 2013 Wiley Publishing Asia Pty Ltd
Early Intervention in Psychiatry
Volume 8, Issue 3, pages 229–239, August 2014
How to Cite
White, T., Mous, S. and Karatekin, C. (2014), Memory-guided saccades in youth-onset psychosis and attention deficit hyperactivity disorder (ADHD). Early Intervention in Psychiatry, 8: 229–239. doi: 10.1111/eip.12038
- Issue published online: 23 JUL 2014
- Article first published online: 28 FEB 2013
- Manuscript Accepted: 28 DEC 2012
- Manuscript Received: 13 SEP 2012
- NWO ZonMw TOP. Grant Number: 91211021
- National Iinstitute of Mental Health (NIMH). Grant Number: 1RO3-MH063150
- NIMH. Grant Number: K08-MH068540
- National Alliance for Research on Schizophrenia and Depression (NARSAD)
- Blowitz-Ridgeway and Essel Foundations
- Minnesota Center for Neurobehavioral Development
- delayed-response task;
- early-onset schizophrenia;
- spatial working memory
Working memory deficits have been shown to be present in children and adolescents with schizophrenia and attention deficit hyperactivity disorder. Considering the differences in clinical characteristics between these disorders, it was the goal of this study to assess differences in the specific components of working memory in children and adolescents with psychosis and attention deficit hyperactivity disorder.
Children and adolescents (age range 8–20 years) with either a non-affective psychotic disorder (n = 25), attention deficit hyperactivity disorder (n = 33) and controls (n = 58) were administered an oculomotor delayed-response task using both a recall and a control condition. Memory-guided saccades were measured during delay periods of 2, 8 and 20 s.
Although both clinical groups were less accurate than controls, there was no evidence of a disproportionate impairment in recall. In addition, there was no evidence of a delay-dependent impairment in psychosis; however, there was a delay-dependent impairment in attention deficit hyperactivity disorder when corrective saccades were included. Speed of information processing was correlated with distance errors in psychosis, suggesting that speed of encoding the stimulus location may have constrained the accuracy of the saccades.
Our findings support impairments during encoding in the psychosis group and a delay-dependent deficit in the attention deficit hyperactivity disorder group.