Declaration of conflict of interest:
Predictors of substance use reduction in an epidemiological first-episode psychosis cohort
Article first published online: 24 JUL 2013
© 2013 Wiley Publishing Asia Pty Ltd
Early Intervention in Psychiatry
How to Cite
Rebgetz, S., Conus, P., Hides, L., Kavanagh, D. J., Cotton, S., Schimmelmann, B. G., McGorry, P. D. and Lambert, M. (2013), Predictors of substance use reduction in an epidemiological first-episode psychosis cohort. Early Intervention in Psychiatry. doi: 10.1111/eip.12067
The study was conducted at EPPIC in Melbourne, and was supported by Eli Lilly Australia in the frame of an investigator initiated trial; however, this company did not have any involvement in the study design, in the collection, analysis and interpretation of data, in the writing of the report and in the decision to submit the paper for publication.
- Article first published online: 24 JUL 2013
- Manuscript Accepted: 20 MAY 2013
- Manuscript Received: 12 DEC 2012
- Eli Lilly Australia
- first episode;
- substance use disorder
To assess the predictors of a significant decrease or cessation of substance use (SU) in a treated epidemiological cohort of first-episode psychosis (FEP) patients.
Participants were FEP patients of the Early Psychosis Prevention and Intervention Centre in Australia. Patients' medical files were reviewed using a standardized file audit. Data on 432 patients with FEP and baseline co-morbid substance use disorder (SUD) were available for analysis. Predictors of reduction/cessation of SU at follow up were examined using logistic regression analyses.
In univariate analyses, a reduction/cessation of SU was predicted by baseline measures reflecting higher education, employment, accommodation with others, cannabis use disorder (CUD) only (rather than poly-SUDs), better global functioning and better premorbid social and occupational functioning, later age at onset of psychosis, and a diagnosis of non-affective psychosis. In multivariate analysis, CUD alone and better premorbid social and occupational functioning remained significant predictors.
Addressing SUDs and social and occupational goals in people with FEP may offer opportunities to prevent SUDs becoming more severe or entrenched. Further longitudinal research on recovery from SU and FEP is needed to disentangle directions of influence and identify key targets for intervention.