Alteration of the N-glycome of bovine milk glycoproteins during early lactation (pages 3769–3781)
Shota Takimori, Hideyuki Shimaoka, Jun-Ichi Furukawa, Tadashi Yamashita, Maho Amano, Naoki Fujitani, Yasuhiro Takegawa, Lennart Hammarström, Imre Kacskovics, Yasuro Shinohara and Shin-Ichiro Nishimura
Article first published online: 8 SEP 2011 | DOI: 10.1111/j.1742-4658.2011.08299.x
Unique alteration of bovine milk N-glycome during early lactation revealed by glycoblotting and MALDI-TOF MS analyses was largely attributable to the dramatic change of the IgG glycosylation pattern around parturition. Bovine FcRn binds IgG2 better than IgG1 suggesting the role of FcRn in the bovine mammary gland is to recycle IgG2 from the udder to blood.