Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma (pages 316–335)
Jing Zhong, Ren-Xian Cao, Xu-Yu Zu, Tao Hong, Jing Yang, Ling Liu, Xin-Hua Xiao, Wen-Jun Ding, Qiang Zhao, Jiang-Hua Liu and Ge-Bo Wen
Article first published online: 9 DEC 2011 | DOI: 10.1111/j.1742-4658.2011.08426.x
Here we identified the molecular and cell biological characterization of three novel PRMT2 splice variants isolated from breast cancer cells. Coimmunoprecipitation assays in MCF7 cells and HepG2 cells, demonstrated that endogenous PRMT2 variants physically interacts with ERα/AR, respectively. Confocal microscopy suggested a colocalization of PRMT2 variants and ERα/AR in a nuclear area.