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Fig. S1. Behavioral (A) and tissue oxygen (TO2) responses in the basolateral amygdala (BLA; B), dorsal hippocampus (dHPC; C) and ventral hippocampus (vHPC; D) during pre-exposure, training and extinction of Pavlovian fear conditioning. Columns 1–4 show mean responses to the five CS− and five CS+ presentations during each day of phase I (pre-exposure, training I, training II and extinction, respectively). Columns 5 and 6 show responses for the first and last CS+ and CS− trials of extinction (i.e. column 5: CS−1 vs. CS+1; column 6: CS−5 vs. CS+5). (A) Mean (±SEM) percentage freezing during the 30 s of the CS− (blue bars) or CS+ (red bars). (B–D) Mean (±SEM) TO2 change from baseline (ΔTO2) during the 30 s of CS− (blue traces) and CS+ (red traces) in 2-s timebins. n.s., no significant difference in paired t-test, or no main effect of CS or CS × timebin interaction; *significant difference in paired t-test (P < 0.05) or main effect of CS (P < 0.05); #CS × timebin interaction (P < 0.05).

Fig. S2. Freezing responses to the CS− (blue) and CS+ (red) during the last five trials of training. There was no evidence of discriminative freezing (i.e. higher freezing during CS+ trials) during any of the training trials.

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