Striatal modulation of BDNF expression using microRNA124a-expressing lentiviral vectors impairs ethanol-induced conditioned-place preference and voluntary alcohol consumption
Article first published online: 19 APR 2013
© 2013 Federation of European Neuroscience Societies and John Wiley & Sons Ltd
European Journal of Neuroscience
Volume 38, Issue 2, pages 2328–2337, July 2013
How to Cite
Bahi, A. and Dreyer, J.-L. (2013), Striatal modulation of BDNF expression using microRNA124a-expressing lentiviral vectors impairs ethanol-induced conditioned-place preference and voluntary alcohol consumption. European Journal of Neuroscience, 38: 2328–2337. doi: 10.1111/ejn.12228
- Issue published online: 14 JUL 2013
- Article first published online: 19 APR 2013
- Manuscript Accepted: 22 MAR 2013
- Manuscript Revised: 21 MAR 2013
- Manuscript Received: 12 NOV 2012
- Swiss National Science Foundation. Grant Numbers: 3100-059350, 3100AO-100686, 31003A-116492
Fig. S1. Histological representation of dissection placements in the dorso-lateral “DLS” (A) and medio-lateral “MLS” striatum (B).
Fig. S2. Mean blood ethanol concentrations following viral injection. (A) Mean BEC of LV-siR124a, LV-Mock and LV-miR124a –injected rats (n = 4, 3, 4). (B) Mean BEC of LV-Mock and LV-BDNF –injected rats (n = 3 & 6). For all groups, viral vectors were injected into the DLS and BEC was assessed following a single injection with ethanol (3 g/kg body weight, i.p.). Blood was collected from the tail vein at various times after injection and analysed to determine the ethanol concentration. Values represent the mean ± SEM. *P < 0.000, the difference between 0.5- and 4-h (repeated measures one-way anova, Bonferroni's post hoc test).
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