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Fig. S1. Altered expression of enzymes regulating sphingolipid metabolism in PGC1a KO mouse. Cerebellar gene expression of sphingolipids enzymes from 8-weeks-old male WT and PGC1a KO mice fed chow. The graph represents fold of change respect to housekeeping gene actin. (n = 6–8). Statistical analysis was performed by using Student t-test (t12 = 2.959. P = 0.011).

Fig. S2. PGC1alpha coordinates the expression of peroxisome-related enzymes in brain. Cerebellar gene expression of peroxisome enzymes from 8-weeks-old male WT and PGC1a KO mice fed chow. The graph represents fold of change respect to housekeeping gene actin. (n = 6–8). Statistical analysis was performed by using Student t-test (Gnpat, t9 = 3.292. P = 0.0093; Pcyt2 t13 = 2.82, P = 0.014).

Fig. S3. PGC1alpha coordinates the ceramide and sphingomyelin synthesis in the lipid rafts microdomains. A–C), Membrane rafts were prepared and analysed as described in Fig. 3. Statistical analysis was performed by using Student t-test. (n = 6–8). CER C18 : 1/16 : 0, t6 = 3.07. P = 0.0218; CER C18 : 1/20 : 0, t6 = 2.430. P =0.05; GC C18 : 1/24 : 0, t6 = 2.810. P = 0.0307; SM C18 : 1/16 : 0, t6 = 2,672. P = 0.0368; SM C18 : 1/24 : 1,t6 = 2.813. P = 0.0306 and SM C18 : 0/20 : 0 t6 = 2.753. P = 0.033.

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