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Data S1. Methods.

Fig. S1. Diagrams of coronal rat brain sections (Paxinos & Watson, 1998) from animals who self-administered nicotine under a (A) fixed-ratio (FR) and (B) progressive-ratio (PR) schedule, the data for which are shown in Fig. 1A and B in the main text, respectively.

Fig. S2. Diagrams of coronal rat brain sections (Paxinos & Watson, 1998) that depict the injection sites for LY235959/saline in the NAcc shell and core in rats that self-administered food under a fixed-ratio schedule, the data for which are shown in Fig. 2 in the main text.

Fig. S3. Diagrams of coronal rat brain sections (Paxinos & Watson, 1998) showing injection sites for LY235959 in the NAcc shell (black circles) in rats used in the nicotine-induced conditioned taste aversion study, the data for which are shown in Fig. 3D in the main text.

Fig. S4. Diagrams of coronal rat brain sections (Paxinos & Watson, 1998) that depict the injection sites for LY235959/saline in the NAcc shell and core in rats used in the cue-induced reinstatement of nicotine seeking experiment, the data of which are shown in Fig. 4A and B in the main text.

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