Fluoxetine rescues impaired hippocampal neurogenesis in a transgenic A53T synuclein mouse model (pages 10–19)
Zacharias Kohl, Beate Winner, Kiren Ubhi, Edward Rockenstein, Michael Mante, Martina Münch, Carolee Barlow, Todd Carter, Eliezer Masliah and Jürgen Winkler
Article first published online: 2 JAN 2012 | DOI: 10.1111/j.1460-9568.2011.07933.x
The accumulation of alpha-synuclein in Lewy bodies and Lewy neurites of different neuronal populations is one of the neuropathological hallmarks in Parkinson disease (PD). Overexpression of human wildtype or mutant alpha-synuclein affects the generation of new neurons in the adult dentate gyrus (DG) of the hippocampus in models of PD.