Ampakine CX546 increases proliferation and neuronal differentiation in subventricular zone stem/progenitor cell cultures (pages 1672–1683)
Clarissa Schitine, Sara Xapelli, Fabienne Agasse, Laura Sardà-Arroyo, Ana P. Silva, Ricardo A. De Melo Reis, Fernando G. de Mello and João O. Malva
Article first published online: 16 APR 2012 | DOI: 10.1111/j.1460-9568.2012.08072.x
Ampakines are chemical compounds known to modulate the properties of ionotropic α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)-subtype glutamate receptors. The functional effects attributed to ampakines involve plasticity and the increase in synaptic efficiency of neuronal circuits, a process that may be intimately associated with differentiation of newborn neurons.