European Journal of Neuroscience

Cover image for Vol. 35 Issue 5

March 2012

Volume 35, Issue 5

Pages 651–804

  1. MOLECULAR AND DEVELOPMENTAL NEUROSCIENCE

    1. Top of page
    2. MOLECULAR AND DEVELOPMENTAL NEUROSCIENCE
    3. Molecular and Developmental Neuroscience
    4. MOLECULAR AND DEVELOPMENTAL NEUROSCIENCE
    5. NEUROSYSTEMS
    6. BEHAVIORAL NEUROSCIENCE
    1.  

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    2. The unfolded protein response in models of human mutant G93A amyotrophic lateral sclerosis (pages 652–660)

      T. Prell, J. Lautenschläger, O. W. Witte, M. T. Carri and J. Grosskreutz

      Article first published online: 6 MAR 2012 | DOI: 10.1111/j.1460-9568.2012.08008.x

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      Recent studies indicate that endoplasmic reticulum (ER) stress is involved in the pathogenesis of familial and sporadic amyotrophic lateral sclerosis (ALS). ER stress occurs when the ER–mitochondria calcium cycle (ERMCC) is disturbed and misfolded proteins accumulate in the ER.

  2. Molecular and Developmental Neuroscience

    1. Top of page
    2. MOLECULAR AND DEVELOPMENTAL NEUROSCIENCE
    3. Molecular and Developmental Neuroscience
    4. MOLECULAR AND DEVELOPMENTAL NEUROSCIENCE
    5. NEUROSYSTEMS
    6. BEHAVIORAL NEUROSCIENCE
    1.  

      Both NKCC1 and anion exchangers contribute to Cl accumulation in postnatal forebrain neuronal progenitors (pages 661–672)

      Lin Sun, Zhiyuan Yu, Wei Wang and Xiuxin Liu

      Article first published online: 6 MAR 2012 | DOI: 10.1111/j.1460-9568.2012.08007.x

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      Neuronal progenitors are continuously generated in the postnatal rodent subventricular zone and migrate along the rostral migratory stream to supply interneurons in the olfactory bulb. Nonsynaptic GABAergic signaling affects the postnatal neurogenesis by depolarizing neuronal progenitors, which depends on an elevated intracellular Cl concentration.

  3. MOLECULAR AND DEVELOPMENTAL NEUROSCIENCE

    1. Top of page
    2. MOLECULAR AND DEVELOPMENTAL NEUROSCIENCE
    3. Molecular and Developmental Neuroscience
    4. MOLECULAR AND DEVELOPMENTAL NEUROSCIENCE
    5. NEUROSYSTEMS
    6. BEHAVIORAL NEUROSCIENCE
    1.  

      Synchronized spike waves in immature dentate gyrus networks (pages 673–681)

      Megumi Seki, Chiaki Kobayashi, Naoya Takahashi, Norio Matsuki and Yuji Ikegaya

      Article first published online: 15 FEB 2012 | DOI: 10.1111/j.1460-9568.2012.07995.x

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      At early developmental stages, immature neuronal networks of the neocortex and hippocampus spontaneously exhibit synchronously oscillating activities, which are believed to play roles in normal circuit maturation. The tissue development of the dentate gyrus (DG) in the hippocampal formation is exceptionally late compared with other brain regions and persists until postnatal periods.

    2. Early olfactory experience induces structural changes in the primary olfactory center of an insect brain (pages 682–690)

      A. Arenas, M. Giurfa, J. C. Sandoz, B. Hourcade, J. M. Devaud and W. M. Farina

      Article first published online: 2 FEB 2012 | DOI: 10.1111/j.1460-9568.2012.07999.x

    3. Lack of dystrophin in mdx mice modulates the expression of genes involved in neuron survival and differentiation (pages 691–701)

      Valerio Licursi, Ivan Caiello, Loredana Lombardi, Maria Egle De Stefano, Rodolfo Negri and Paola Paggi

      Article first published online: 7 FEB 2012 | DOI: 10.1111/j.1460-9568.2011.07984.x

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      Duchenne muscular dystrophy is an X-linked disease characterized by progressive and lethal muscular wasting. Dystrophic patients, however, are also afflicted by several neurological disorders, the importance of which is generally underestimated.

  4. NEUROSYSTEMS

    1. Top of page
    2. MOLECULAR AND DEVELOPMENTAL NEUROSCIENCE
    3. Molecular and Developmental Neuroscience
    4. MOLECULAR AND DEVELOPMENTAL NEUROSCIENCE
    5. NEUROSYSTEMS
    6. BEHAVIORAL NEUROSCIENCE
    1. Hippocampal CA3 and CA2 have distinct bilateral innervation patterns to CA1 in rodents (pages 702–710)

      Yoshiaki Shinohara, Aki Hosoya, Kazuko Yahagi, Alex S. Ferecskó, Kunio Yaguchi, Attila Sík, Makoto Itakura, Masami Takahashi and Hajime Hirase

      Article first published online: 17 FEB 2012 | DOI: 10.1111/j.1460-9568.2012.07993.x

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      Ipsilateral and contralateral hippocampal CA3–CA1 and CA2–CA1 projections were investigated in adult male Long–Evans rats by retrograde tracing. Injection of the retrograde tracer cholera toxin subunit B in the strata oriens and radiatum of dorsal CA1 resulted in labeling of predominantly pyramidal cells in ipsilateral and contralateral CA3 and CA2.

    2. Lateral regions of the rodent striatum reveal elevated glutamate decarboxylase 1 mRNA expression in medium-sized projection neurons (pages 711–722)

      Stefan Trifonov, Takeshi Houtani, Masahiko Kase, Kazunori Toida, Masato Maruyama, Yuji Yamashita, Jun-Ichi Shimizu and Tetsuo Sugimoto

      Article first published online: 15 FEB 2012 | DOI: 10.1111/j.1460-9568.2012.08001.x

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      The GABA-synthesizing enzymes glutamate decarboxylase (GAD)1 and GAD2 are universally contained in GABAergic neurons in the central nervous system of the mouse and rat. The two isoforms are almost identically expressed throughout the brain and spinal cord.

    3. Subpopulations of cholinergic, GABAergic and glutamatergic neurons in the pedunculopontine nucleus contain calcium-binding proteins and are heterogeneously distributed (pages 723–734)

      Cristina Martinez-Gonzalez, Hui-Ling Wang, Benjamin R. Micklem, J. Paul Bolam and Juan Mena-Segovia

      Article first published online: 22 FEB 2012 | DOI: 10.1111/j.1460-9568.2012.08002.x

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      Neurons in the pedunculopontine nucleus (PPN) are highly heterogeneous in their discharge properties, their neurochemical markers, their pattern of connectivity and the behavioural processes in which they participate. Three main transmitter phenotypes have been described, cholinergic, GABAergic and glutamatergic, and yet electrophysiological evidence suggests heterogeneity within these subtypes.

    4. Ablation of serum response factor in dopaminergic neurons exacerbates susceptibility towards MPTP-induced oxidative stress (pages 735–741)

      Claus Rieker, Andreas Schober, Ainhoa Bilbao, Günther Schütz and Jan Rodriguez Parkitna

      Article first published online: 22 FEB 2012 | DOI: 10.1111/j.1460-9568.2012.08003.x

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      The high susceptibility of dopaminergic (DA) neurons to cellular stress is regarded as a primary cause of Parkinson’s disease. Here we investigate the role of the serum response factor (SRF), an important regulator of anti-apoptotic responses, for the survival of DA neurons in mice.

    5. Scaled correlation analysis: a better way to compute a cross-correlogram (pages 742–762)

      Danko Nikolić, Raul C. Mureşan, Weijia Feng and Wolf Singer

      Article first published online: 13 FEB 2012 | DOI: 10.1111/j.1460-9568.2011.07987.x

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      When computing a cross-correlation histogram, slower signal components can hinder the detection of faster components, which are often in the research focus. For example, precise neuronal synchronization often co-occurs with slow co-variation in neuronal rate responses.

  5. BEHAVIORAL NEUROSCIENCE

    1. Top of page
    2. MOLECULAR AND DEVELOPMENTAL NEUROSCIENCE
    3. Molecular and Developmental Neuroscience
    4. MOLECULAR AND DEVELOPMENTAL NEUROSCIENCE
    5. NEUROSYSTEMS
    6. BEHAVIORAL NEUROSCIENCE
    1. Dopamine modulates memory consolidation of discrimination learning in the auditory cortex (pages 763–774)

      Horst Schicknick, Nicole Reichenbach, Karl-Heinz Smalla, Henning Scheich, Eckart D. Gundelfinger and Wolfgang Tischmeyer

      Article first published online: 17 FEB 2012 | DOI: 10.1111/j.1460-9568.2012.07994.x

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      In Mongolian gerbils, the auditory cortex is critical for discriminating rising vs. falling frequency-modulated tones. Based on our previous studies, we hypothesized that dopaminergic inputs to the auditory cortex during and shortly after acquisition of the discrimination strategy control long-term memory formation.

    2. Inactivation of the central nucleus of the amygdala reduces the effect of punishment on cocaine self-administration in rats (pages 775–783)

      YueQiang Xue, Jeffery D. Steketee and WenLin Sun

      Article first published online: 6 FEB 2012 | DOI: 10.1111/j.1460-9568.2012.08000.x

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      Continued cocaine use despite the negative consequences is a hallmark of cocaine addiction. One such consequence is punishment, which is often used by society to curb cocaine use. Unfortunately, we know little about the mechanism involved in regulation by punishment of cocaine use

    3. Striatal direct pathway modulates response time in execution of visual discrimination (pages 784–797)

      Ryoji Fukabori, Kana Okada, Kayo Nishizawa, Nobuyuki Kai, Kenta Kobayashi, Motokazu Uchigashima, Masahiko Watanabe, Yuji Tsutsui and Kazuto Kobayashi

      Article first published online: 22 FEB 2012 | DOI: 10.1111/j.1460-9568.2012.08005.x

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      The dorsal striatum in the basal ganglia circuitry is a principal structure that mediates the acquisition and performance of instrumental learning. The projections from the dorsal striatum are composed of two subpopulations of medium spiny neurons that constitute the direct and indirect pathways.

    4. Orexin / hypocretin 1 receptor antagonist reduces heroin self-administration and cue-induced heroin seeking (pages 798–804)

      Rachel J. Smith and Gary Aston-Jones

      Article first published online: 22 FEB 2012 | DOI: 10.1111/j.1460-9568.2012.08013.x

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      The orexin/hypocretin system is involved in several addiction-related behaviors. In the present experiments, we examined the involvement of orexin in heroin reinforcement and relapse by administering the orexin 1 receptor antagonist SB-334867 prior to heroin self-administration or prior to cue-induced or heroin-induced reinstatement of extinguished heroin seeking in male Sprague–Dawley rats. SB-334867 (30 mg/kg, intraperitoneal) reduced heroin intake during self-administration under fixed ratio-1 and progressive ratio schedules. SB-334867 also attenuated reinstatement of heroin seeking elicited by cues, but not reinstatement elicited by a heroin prime.

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