Cognitive deficits in a mouse model of pre-manifest Parkinson’s disease (pages 870–882)
Iddo Magen, Sheila M. Fleming, Chunni Zhu, Eddie C. Garcia, Katherine M. Cardiff, Diana Dinh, Krystal De La Rosa, Maria Sanchez, Eileen Ruth Torres, Eliezer Masliah, J. David Jentsch and Marie-Françoise Chesselet
Article first published online: 22 FEB 2012 | DOI: 10.1111/j.1460-9568.2012.08012.x
Early cognitive deficits are increasingly recognized in patients with Parkinson’s disease (PD), and represent an unmet need for the treatment of PD. These early deficits have been difficult to model in mice, and their mechanisms are poorly understood.