Stress shifts the response of the bed nucleus of the stria terminalis to an anxiogenic mode (pages 3396–3406)
Ana P. Ventura-Silva, José M. Pêgo, João C. Sousa, Ana R. Marques, Ana J. Rodrigues, Fernanda Marques, João J. Cerqueira, Osborne F. X. Almeida and Nuno Sousa
Version of Record online: 28 AUG 2012 | DOI: 10.1111/j.1460-9568.2012.08262.x
We found that exposure to chronic stress induces a pattern of cFOS activation in specific nuclei of the BNST that is similar to the one induced by exposure to an anxiogenic stimuli. This altered activation can be correlated with molecular changes within specific BNST divisions. In particular, chronic stress induces a decrease in CRFR1 expression while increasing the expression of CRFR2, GABAA receptor and NR2B in BNST.