Altered spatial learning, cortical plasticity and hippocampal anatomy in a neurodevelopmental model of schizophrenia-related endophenotypes (pages 2773–2781)
P. Leon Brown, Paul D. Shepard, Greg I. Elmer, Sara Stockman, Rebecca McFarland, Cheryl L. Mayo, Jean Lud Cadet, Irina N. Krasnova, Martin Greenwald, Carrie Schoonover and Michael W. Vogel
Article first published online: 5 JUL 2012 | DOI: 10.1111/j.1460-9568.2012.08204.x
Rats exposed to the DNA methylating agent methylazoxymethanol (MAM) on E17 show deficits as adults that model some of the neuropathological and behavioral changes observed in schizophrenia. It is presently unknown whether these changes generalize to other antimitotic agents administered later in development. Here we show that exposure to the antimitotic agent Ara-C between E19.5 and E20.5 recapitulates some of the changes observed in MAM-treated animals and in patients with schizophrenia.