Stress-induced sensitization to cocaine: actin cytoskeleton remodeling within mesocorticolimbic nuclei (pages 3103–3117)
Maria A. Esparza, Flavia Bollati, Constanza Garcia-Keller, Miriam B. Virgolini, Lidia M. Lopez, Alicia Brusco, Hao-Wei Shen, Peter W. Kalivas and Liliana M. Cancela
Version of Record online: 12 AUG 2012 | DOI: 10.1111/j.1460-9568.2012.08239.x
This study shows that a history of repeated stress alters the capacity of a subsequent cocaine injection to modulate dendritic spine morphology (size of PSD), actin dynamics and AMPAR expression in the NAc. Furthermore, the alterations in actin dynamics regulate AMPAR surface expression in the NAc after cocaine in the prior repeated stress group, which is a shared molecular mechanism between stress- and drug-induced sensitization to cocaine.