Diet-dependent modulation of hippocampal expression of endocannabinoid signaling-related proteins in cannabinoid antagonist-treated obese rats (pages 105–117)
Patricia Rivera, María Jesús Luque-Rojas, Antoni Pastor, Eduardo Blanco, Francisco J. Pavón, Antonia Serrano, Ana Crespillo, Margarita Vida, Jesús M. Grondona, Manuel Cifuentes, Francisco J. Bermúdez-Silva, Rafael de la Torre, Fernando Rodríguez de Fonseca and Juan Suárez
Article first published online: 3 OCT 2012 | DOI: 10.1111/ejn.12012
Diet-induced obesity produces changes in endocannabinoid signaling (ECS), influencing the regulation of energy homeostasis. Recently, we demonstrated that in high-fat diet-fed rats, blockade of CB1 receptor by AM251 not only reduced body weight but also increased adult neurogenesis in the hippocampus, suggesting an influence of diet on hippocampal cannabinoid function.