Lack of galectin-3 speeds Wallerian degeneration by altering TLR and pro-inflammatory cytokine expressions in injured sciatic nerve (pages 1682–1690)
Bruno Siqueira Mietto, Sofia Jurgensen, Lucinéia Alves, Cyntia Pecli, Marcelo Sampaio Narciso, Iranaia Assunção-Miranda, Dea Maria Serra Villa-Verde, Flávia Regina de Souza Lima, João Ricardo Lacerda de Menezes, Cláudia Farias Benjamim, Marcelo Torres Bozza and Ana Maria Blanco Martinez
Article first published online: 14 FEB 2013 | DOI: 10.1111/ejn.12161
The lack of Gal-3 after sciatic nerve injury speeds Wallerian degeneration (WD) by augmenting the inflammatory profile of WD and by accelerating myelin breakdown and clearance. In addition, the absence of Gal-3 in macrophages and Schwann cells results in an improvement in their phagocytic potential.