Calorie restriction alleviates the age-related decrease in neural progenitor cell division in the aging brain (pages 1987–1993)
June-Hee Park, Zachary Glass, Kasim Sayed, Tatyana V. Michurina, Alexander Lazutkin, Olga Mineyeva, Dmitry Velmeshev, Walter F. Ward, Arlan Richardson and Grigori Enikolopov
Version of Record online: 16 JUN 2013 | DOI: 10.1111/ejn.12249
We examined the response of adult stem and progenitor cells in the hippocampus to an extended period of calorie restriction and rapamycin supplementation by using a reporter mouse line in which expression of GFP marks adult stem and progenitor cells. Upper left image shows the hippocampus of a young (3 weeks) animal for comparison. We found that calorie restriction increases proliferation of neural stem and progenitor cells in aging females.