European Journal of Neuroscience

Cover image for Vol. 37 Issue 4

February 2013

Volume 37, Issue 4

Pages 508–678

  1. MOLECULAR AND DEVELOPMENTAL NEUROSCIENCE

    1. Top of page
    2. MOLECULAR AND DEVELOPMENTAL NEUROSCIENCE
    3. NEUROSYSTEMS
    4. BEHAVIORAL NEUROSCIENCE
    5. COGNITIVE NEUROSCIENCE
    1. VEGF-dependent continuous angiogenesis in the median eminence of adult mice (pages 508–518)

      S. Morita, S. Ukai and S. Miyata

      Article first published online: 22 NOV 2012 | DOI: 10.1111/ejn.12047

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      The quantitative analysis of BrdU-labeling showed active proliferation of endothelial cells in the ME of adult mice (53.8 times greater that in the cerebral cortex). Vascular endothelial growth factor (VEGF) and VEGF receptor 2 were expressed highly at presynaptic terminals and endothelial cells in the external zone of the ME, respectively. SU11248, a VEGFR- and PDGFR-associated tyrosine kinase inhibitor decreased the number of BrdU-positive endothelial cells.

    2. Axonal growth towards Xenopus skin in vitro is mediated by matrix metalloproteinase activity (pages 519–531)

      David Tonge, Ning Zhu, Steven Lynham, Pascal Leclere, Alison Snape, Alison Brewer, Uwe Schlomann, Taheera Ferdous, Charlene Tennyson, Jörg W. Bartsch, Malcolm Ward and John Pizzey

      Article first published online: 6 DEC 2012 | DOI: 10.1111/ejn.12075

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      The mechanisms for long-range signalling from the periphery for axon attraction remain largely unknown. Here we show by a proteomic approach that Xenopus skin synthesises and secretes the matrix metalloproteinase MMP-18. We also demonstrate that MMP-18 is capable of promoting directed axonal growth from dorsal root ganglion- peripheral nerve preparations.

    3. Type 2 K+–Cl cotransporter is preferentially recruited to climbing fiber synapses during development and the stellate cell-targeting dendritic zone at adulthood in cerebellar Purkinje cells (pages 532–543)

      Issei Kawakita, Motokazu Uchigashima, Kohtarou Konno, Taisuke Miyazaki, Miwako Yamasaki and Masahiko Watanabe

      Article first published online: 6 DEC 2012 | DOI: 10.1111/ejn.12076

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      Postnatal expression of type-2 K+-Cl cotransporter (KCC2) in neurons lowers the Cl equilibrium potential to values more negative than the resting potential, thereby converting the action of Cl-permeable GABAA and glycine receptors from excitatory to inhibitory. In the present study, we investigated spatiotemporal expression of KCC2 in mouse cerebella, particularly focusing on Purkinje cells (PCs).

    4. Direct binding of GABAA receptor β2 and β3 subunits to gephyrin (pages 544–554)

      Sarah Kowalczyk, Aline Winkelmann, Birthe Smolinsky, Benjamin Förstera, Ines Neundorf, Guenter Schwarz and Jochen C. Meier

      Article first published online: 4 DEC 2012 | DOI: 10.1111/ejn.12078

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      GABAA receptor (GABAAR) α-subunits were recently shown to interact with gephyrin, which contributes to postsynaptic receptor stabilisation. We show that the C-terminal parts of cytoplasmic loops between transmembrane domains 3 and 4 of GABAAR β2 and β3 subunits also interact with gephyrin. Compared with the GlyR β loop, the binding of GABAAR β2 and β3 loops to gephyrin showed a twenty fold lower affinity, which is in the range of the KD values that were determined for GABAAR α-subunits. The identified gephyrin-binding sequences of β2 and β3 subunits also mediate postsynaptic localisation of corresponding GlyR α1-GABAAR β chimaeras in cortical neurons. Thus, at least five different GABAAR subunits can interact with gephyrin.

  2. NEUROSYSTEMS

    1. Top of page
    2. MOLECULAR AND DEVELOPMENTAL NEUROSCIENCE
    3. NEUROSYSTEMS
    4. BEHAVIORAL NEUROSCIENCE
    5. COGNITIVE NEUROSCIENCE
    1. Alterations in Purkinje cell GABAA receptor pharmacology following oxygen and glucose deprivation and cerebral ischemia reveal novel contribution of β1-subunit-containing receptors (pages 555–563)

      Melissa H. Kelley, Justin Ortiz, Kaori Shimizu, Himmat Grewal, Nidia Quillinan and Paco S. Herson

      Article first published online: 26 NOV 2012 | DOI: 10.1111/ejn.12064

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      Cerebellar Purkinje cells (PCs) are particularly sensitive to cerebral ischemia and decreased GABAA receptor function following injury is thought to contribute to PC sensitivity to ischemia-induced excitotoxicity. Here we examined the functional properties of the GABAA receptors that are spared following ischemia.

    2. Distributed auditory sensory input within the mouse olfactory cortex (pages 564–571)

      Adrienn G. Varga and Daniel W. Wesson

      Article first published online: 29 NOV 2012 | DOI: 10.1111/ejn.12063

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      While the olfactory piriform cortex is commonly considered an ‘olfactory’ brain structure, here with extracellular multi- and single-unit recordings from mice, we demonstrate the presence of auditory sensory input in > 25% of piriform cortex neurons. These results suggest that a major portion of odor-evoked output from the olfactory bulb is subject to auditory sensory input in a manner which may modulate odor information processing, odor-guided behaviors, and perception.

    3. Neuropeptide receptors provide a signalling pathway for trigeminal modulation of olfactory transduction (pages 572–582)

      Philipp Daiber, Federica Genovese, Valentin A. Schriever, Thomas Hummel, Frank Möhrlen and Stephan Frings

      Article first published online: 3 DEC 2012 | DOI: 10.1111/ejn.12066

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      Co-stimulation with an irritant attenuates odour perception. This can be shown with the floral odorant PEA and the irritant CO2 in human subjects. The effect is recapitulated in the rat olfactory system when the trigeminal peptide CGRP is co-applied with PEA. This phenomenon is the result of a modulatory interaction between the olfactory and trigeminal systems in the nose. It is mediated by neuropeptide receptors expressed by olfactory receptor neurons.

    4. Cellular neuroanatomy of rat presubiculum (pages 583–597)

      Jean Simonnet, Emmanuel Eugène, Ivan Cohen, Richard Miles and Desdemona Fricker

      Article first published online: 26 NOV 2012 | DOI: 10.1111/ejn.12065

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      The presubiculum is situated at the transition between archicortex and neocortex. Cluster analysis identified groups of neurons with similar electrical and anatomical properties situated in superficial, intermediate and deep layers. Layer IV cells, of the lamina dissecans, fired in bursts of action potentials. Principal cells from other layers discharged regularly, with very little frequency adaptation, consistent with a possible role in a maintained signalling of head direction.

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      Insights on the neural basis of motor plasticity induced by theta burst stimulation from TMS–EEG (pages 598–606)

      Marine Vernet, Shahid Bashir, Woo-Kyoung Yoo, Jennifer M. Perez, Umer Najib and Alvaro Pascual-Leone

      Article first published online: 28 NOV 2012 | DOI: 10.1111/ejn.12069

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      Continuous theta-burst stimulation applied to the motor cortex is a noninvasive brain stimulation protocol suppressing activity in the stimulated area. We show that cTBS (i) modulates a combination of TMS-evoked EEG potentials, providing a measure of excitability; (ii) decreases TMS-induced and increased resting oscillations in theta band, and has the opposite effects in beta band, consistent with hypothetical (de)synchronization mechanisms of active oscillators. Thus, cTBS exerts a complex, system-level impact on the brain.

  3. BEHAVIORAL NEUROSCIENCE

    1. Top of page
    2. MOLECULAR AND DEVELOPMENTAL NEUROSCIENCE
    3. NEUROSYSTEMS
    4. BEHAVIORAL NEUROSCIENCE
    5. COGNITIVE NEUROSCIENCE
    1. BDNF-mediated regulation of ethanol consumption requires the activation of the MAP kinase pathway and protein synthesis (pages 607–612)

      Jerome Jeanblanc, Marian L. Logrip, Patricia H. Janak and Dorit Ron

      Article first published online: 28 NOV 2012 | DOI: 10.1111/ejn.12067

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      We identified a molecular mechanism by which the neurotrophic factor BDNF, in the dorsolateral striatum (DLS), attenuates rat operant self-administration of alcohol. Specifically, we show that infusion of BDNF into the DLS activates the MAP kinase pathway, presumably ERK1/2, which in turn increases protein synthesis resulting in the reduction of alcohol intake.

    2. Lesion of medial prefrontal dopamine terminals abolishes habituation of accumbens shell dopamine responsiveness to taste stimuli (pages 613–622)

      Zisis Bimpisidis, Maria Antonietta De Luca, Augusta Pisanu and Gaetano Di Chiara

      Article first published online: 6 DEC 2012 | DOI: 10.1111/ejn.12068

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      In this study we tested the hypothesis of an inhibitory influence of mPFC DA on NAc DA. We investigated by in vivo microdialysis the effect of mPFC 6-OHDA lesions on the NAc DA response to taste stimuli. The main finding of the study is that 6-OHDA lesions of the mPFC alter NAc DA responsiveness to gustatory stimuli. In particular, mPFC 6-OHDA lesions abolished one trial habituation of NAc shell DA response to taste.

    3. Conditioned enhancement of firing rates and synchrony of hippocampal neurons and firing rates of motor cortical neurons in rats (pages 623–639)

      Yoshio Sakurai and Susumu Takahashi

      Article first published online: 29 NOV 2012 | DOI: 10.1111/ejn.12070

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      We examined the ability of closely neighboring groups of neurons in the motor cortex and hippocampus to enhance their activities by neuronal operant conditioning. The firing rates of motor cortical and hippocampal neuron groups increased rapidly and contingency of reward on firing synchrony resulted in selective enhancement of firing synchrony of only hippocampal neuron pairs. The conditioning enhanced the firing rates and synchrony of only some neurons and neuron pairs in each group.

    4. Dissociable contributions of the ventral hippocampus and orbitofrontal cortex to decision-making with a delayed or uncertain outcome (pages 640–647)

      Andrew R. Abela and Yogita Chudasama

      Article first published online: 28 NOV 2012 | DOI: 10.1111/ejn.12071

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      In this study, we show a double dissociation between the ventral hippocampus and orbitofrontal cortex in decisions that involve choices with delayed or uncertain outcomes. Their contrasting functions highlight the independent contributions of these structures to decision making despite their anatomical interconnection.

    5. Lateral hypothalamic involvement in feeding elicited from the ventral pallidum (pages 648–653)

      Thomas R. Stratford and David Wirtshafter

      Article first published online: 29 NOV 2012 | DOI: 10.1111/ejn.12077

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      Intense feeding can be elicited by injections of bicuculline into the VPm. We examined feeding following unilateral injections of bicuculline into the VPm made either ipsilateral or contralateral to a unilateral excitotoxic lesion of the LH in rats. Lesions of the LH attenuated feeding induced from the ipsilateral VPm, but significantly potentiated feeding elicited from the contralateral VPm. Thus the LH is causally involved in mediating the ingestive effects produced by activation of the VPm.

  4. COGNITIVE NEUROSCIENCE

    1. Top of page
    2. MOLECULAR AND DEVELOPMENTAL NEUROSCIENCE
    3. NEUROSYSTEMS
    4. BEHAVIORAL NEUROSCIENCE
    5. COGNITIVE NEUROSCIENCE
    1. Informal musical activities are linked to auditory discrimination and attention in 2–3-year-old children: an event-related potential study (pages 654–661)

      V. Putkinen, M. Tervaniemi and M. Huotilainen

      Article first published online: 21 NOV 2012 | DOI: 10.1111/ejn.12049

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      The relation between informal musical activities at home and electrophysiological indices of neural auditory change detection was investigated in 2-3-year-old children. Auditory event-related potentials were recorded in a multi-feature paradigm that included frequency, duration, intensity, direction, and gap deviants and attention catching novel sounds.

    2. Visual mismatch negativity is sensitive to symmetry as a perceptual category (pages 662–667)

      Krisztina Kecskés-Kovács, István Sulykos and István Czigler

      Article first published online: 21 NOV 2012 | DOI: 10.1111/ejn.12061

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      The system underlying the vMMN is sensitive to symmetry as perceptual category, as per that is capable of coding the regular presentation of symmetric patterns (standards) accordingly the appearances of the rare random pattern (deviant) elicit the vMMN component. ERP difference was found in two latency ranges (112-120 and 284-292 ms) at the occipital locations, we consider two negativities as valid error signals, that are organised in cascade mode.

    3. Complementary roles of medial temporal lobes and mid-dorsolateral prefrontal cortex for working memory for novel and familiar trial-unique visual stimuli (pages 668–678)

      Karin Schon, Robert S. Ross, Michael E. Hasselmo and Chantal E. Stern

      Article first published online: 21 NOV 2012 | DOI: 10.1111/ejn.12062

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      We contrasted fMRI activity for working memory for trial-unique familiar vs. novel scenes at encoding, maintenance, and retrieval using a Sternberg task. Our findings demonstrate that the observed novelty effect in the MTL during working memory encoding and maintenance is specific to novel stimuli, regardless of stimulus trial-uniqueness. Our results show that the mid-dlPFC is recruited for monitoring of scene familiarity during encoding and retrieval in the context of a working memory task.

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