Axonal growth towards Xenopus skin in vitro is mediated by matrix metalloproteinase activity (pages 519–531)
David Tonge, Ning Zhu, Steven Lynham, Pascal Leclere, Alison Snape, Alison Brewer, Uwe Schlomann, Taheera Ferdous, Charlene Tennyson, Jörg W. Bartsch, Malcolm Ward and John Pizzey
Article first published online: 6 DEC 2012 | DOI: 10.1111/ejn.12075
The mechanisms for long-range signalling from the periphery for axon attraction remain largely unknown. Here we show by a proteomic approach that Xenopus skin synthesises and secretes the matrix metalloproteinase MMP-18. We also demonstrate that MMP-18 is capable of promoting directed axonal growth from dorsal root ganglion- peripheral nerve preparations.