Motor activity affects adult skeletal muscle re-innervation acting via tyrosine kinase receptors (pages 1394–1403)
Stefano Sartini, Fanny Bartolini, Patrizia Ambrogini, Michele Betti, Stefano Ciuffoli, Davide Lattanzi, Michael Di Palma and Riccardo Cuppini
Version of Record online: 3 FEB 2013 | DOI: 10.1111/ejn.12130
During muscle re-innervation after nerve crush, running activity increases multiple innervation (A) of adult rat soleus muscle cells with consequent faster muscle re-innervation (B). We found increased levels of muscle BDNF in runner rats that, acting via TrkB receptors (C), induced axon sprouting to re-innervate skeletal muscle (D). The up-regulation of muscle BDNF expression by motor activity may be a tool with applications in functional rehabilitation programs of injured patients.