Traits of fear resistance and susceptibility in an advanced intercross line (pages 3314–3324)
Jennifer L. McGuire, Hadley C. Bergstrom, Clarissa C. Parker, Thien Le, Maria Morgan, Haiying Tang, Reed G. Selwyn, Afonso C. Silva, Kwang Choi, Robert J. Ursano, Abraham A. Palmer and Luke R. Johnson
Article first published online: 22 AUG 2013 | DOI: 10.1111/ejn.12337
Through short-term selection in a B6D2 advanced intercross line we created mouse populations divergent for the retention of Pavlovian fear memory. Trait distinctions in HPA-axis drive and fear network circuitry could be made between naïve animals in the two lines. These data demonstrate underlying physiological and neurological differences between Fear-Susceptible and Fear-Resistant animals in a natural population. F-S and F-R mice may therefore be relevant to a spectrum of disorders including depression, anxiety disorders and PTSD for which altered fear processing occurs.