European Journal of Neuroscience

Cover image for Vol. 38 Issue 9

November 2013

Volume 38, Issue 9

Pages 3261–3383

  1. REVIEW

    1. Top of page
    2. REVIEW
    3. DEVELOPMENTAL NEUROSCIENCE
    4. BEHAVIORAL NEUROSCIENCE
    5. COGNITIVE NEUROSCIENCE
    1. Brain-derived neurotrophic factor interacts with astrocytes and neurons to control respiration (pages 3261–3269)

      Céline Caravagna, Jorge Soliz and Tommy Seaborn

      Article first published online: 11 AUG 2013 | DOI: 10.1111/ejn.12320

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      Current knowledge on Rett syndrome and on respective role of astrocytes and BDNF in respiratory control and rhythmogenesis lead us to hypothesize to a BDNF-mediated control of the communication between neurons and astrocytes in the maintenance of a neuronal network capable to generate a stable respiratory rhythm. Understanding the link between glial cells and BDNF signaling in respiratory control would be helpful to refine comprehension of pathologies associated with respiratory disturbances.

  2. DEVELOPMENTAL NEUROSCIENCE

    1. Top of page
    2. REVIEW
    3. DEVELOPMENTAL NEUROSCIENCE
    4. BEHAVIORAL NEUROSCIENCE
    5. COGNITIVE NEUROSCIENCE
    1. Impaired presynaptic function and elimination of synapses at premature stages during postnatal development of the cerebellum in the absence of CALEB (CSPG5/neuroglycan C) (pages 3270–3280)

      René Jüttner, Dirk Montag, Rogerio B. Craveiro, Aleksei Babich, Petra Vetter and Fritz G. Rathjen

      Article first published online: 25 JUL 2013 | DOI: 10.1111/ejn.12313

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      CALEB (CSPG5 or neuroglycan C) is a neural chondroitinsulfate- and an EGF-domain containing transmembrane protein. Analysis of the neuronal connectivity of Purkinje cells by patch-clamp recordings demonstrated impairments of presynaptic maturation of inhibitory synapses in a constitutive CALEB knockout mouse. Furthermore, the elimination of supernumerary climbing fiber synapses on Purkinje cells was found to occur at earlier developmental stages in the absence of CALEB.

    2. Early postnatal motor experience shapes the motor properties of C57BL/6J adult mice (pages 3281–3291)

      Nadjet Serradj, Florence Picquet and Marc Jamon

      Article first published online: 21 JUL 2013 | DOI: 10.1111/ejn.12311

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      This study aimed to evaluate the long-term consequences of early motor training on the muscle phenotype and motor output of middle-aged mice, C57BL/6J. Neonatal mice were subjected to a variety of motor training procedures, for 3 weeks during the period of acquisition of locomotion.

    3. Relationships between radial glial progenitors and 5-HT neurons in the paraventricular organ of adult zebrafish – potential effects of serotonin on adult neurogenesis (pages 3292–3301)

      María Rita Pérez, Elisabeth Pellegrini, Joel Cano-Nicolau, Marie-Madeleine Gueguen, Dounia Menouer-Le Guillou, Yohann Merot, Colette Vaillant, Gustavo M. Somoza and Olivier Kah

      Article first published online: 25 AUG 2013 | DOI: 10.1111/ejn.12348

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      5HT neurons of the zebrafish caudal hypothalamus are closely associated with radial glia cells. 5HT neurons of the zebrafish caudal hypothalamus are generated by neighbouring radial glial progenitors. Inhibiting 5HT synthesis reduces adult neurogenesis in the zebrafish hypothalamus.

  3. BEHAVIORAL NEUROSCIENCE

    1. Top of page
    2. REVIEW
    3. DEVELOPMENTAL NEUROSCIENCE
    4. BEHAVIORAL NEUROSCIENCE
    5. COGNITIVE NEUROSCIENCE
    1. The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata (pages 3302–3313)

      Martin Carbó Tano, Victor A. Molina and Maria Eugenia Pedreira

      Article first published online: 5 AUG 2013 | DOI: 10.1111/ejn.12328

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      Different experimental protocols and pharmacological treatments were used to examine the effects of GABAergic compounds on extinction learning, consolidation, and expression. Our results indicate that an active GABAergic system impedes the consolidation of extinction memory, nevertheless, we also show that it is necessary for the acquisition of the extinction memory. The results presented here about the neural basis of extinction learning can lead to potential new pharmacological treatments.

    2. Traits of fear resistance and susceptibility in an advanced intercross line (pages 3314–3324)

      Jennifer L. McGuire, Hadley C. Bergstrom, Clarissa C. Parker, Thien Le, Maria Morgan, Haiying Tang, Reed G. Selwyn, Afonso C. Silva, Kwang Choi, Robert J. Ursano, Abraham A. Palmer and Luke R. Johnson

      Article first published online: 22 AUG 2013 | DOI: 10.1111/ejn.12337

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      Through short-term selection in a B6D2 advanced intercross line we created mouse populations divergent for the retention of Pavlovian fear memory. Trait distinctions in HPA-axis drive and fear network circuitry could be made between naïve animals in the two lines. These data demonstrate underlying physiological and neurological differences between Fear-Susceptible and Fear-Resistant animals in a natural population. F-S and F-R mice may therefore be relevant to a spectrum of disorders including depression, anxiety disorders and PTSD for which altered fear processing occurs.

    3. c-fos down-regulation inhibits testosterone-dependent male sexual behavior and the associated learning (pages 3325–3337)

      Neville-Andrew Niessen, Jacques Balthazart, Gregory F. Ball and Thierry D. Charlier

      Article first published online: 29 JUL 2013 | DOI: 10.1111/ejn.12321

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      Daily ICV injections of an antisense oligodeoxynucleotide targeting c-fos (AS) inhibited expression of copulatory behavior as well as acquisition of the learned social proximity response, a form of appetitive sexual behavior. A significant reduction of the number of c-fos-positive cells in the medial preoptic area but not in other brain regions was also observed. The data suggest that c-fos expression in the preoptic area modulates copulatory behavior and sexual learning in male quail.

    4. Maximized song learning of juvenile male zebra finches following BDNF expression in the HVC (pages 3338–3344)

      Falk Dittrich, Andries ter Maat, Rene F. Jansen, Anton Pieneman, Moritz Hertel, Carolina Frankl-Vilches and Manfred Gahr

      Article first published online: 11 AUG 2013 | DOI: 10.1111/ejn.12329

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      Song sensorimotor learning and song production of birds is controlled by a set of interconnected brain nuclei, the song control system. In male zebra finches, the beginning of the sensorimotor phase of song learning parallels an increase of the brain-derived neurotrophic factor (BDNF) in just one part of the song control system, the forebrain nucleus HVC. The transient BDNF-mRNA upregulation in the HVC results in a maximized copying of song syllables indicating that HVC anchored mechanisms are limiting sensorimotor vocal learning.

    5. Fatherhood reduces the survival of adult-generated cells and affects various types of behavior in the prairie vole (Microtus ochrogaster ) (pages 3345–3355)

      Claudia Lieberwirth, Yue Wang, Xixi Jia, Yan Liu and Zuoxin Wang

      Article first published online: 31 JUL 2013 | DOI: 10.1111/ejn.12323

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      Fatherhood, but not pup exposure, significantly reduced cell survival (assessed by BrdU-labeling) in the male prairie vole amygdala, dentate gyrus, and ventromedial hypothalamus without altering cell proliferation. In addition, fatherhood increased anxiety- and depression-like behaviors as well as altered aggression and social recognition memory in the male prairie vole. *P < 0.05 and **P < 0.01. Error bars represent SEM.

    6. Luminance, but not chromatic visual pathways, mediate amplification of conditioned danger signals in human visual cortex (pages 3356–3362)

      Andreas Keil, Vladimir Miskovic, Michael J. Gray and Jasna Martinovic

      Article first published online: 28 JUL 2013 | DOI: 10.1111/ejn.12316

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      Experience shapes visual cortical processing in humans, but the mechanisms mediating experience-related sensory changes are poorly understood. We used stimuli driving different aspects of the visual brain as conditioned threat cues in a classical differential fear-conditioning paradigm. Electrophysiological recordings showed pronounced visuo-cortical changes in retinotopic areas when threat was conveyed by luminance, but not chromatic stimuli.

  4. COGNITIVE NEUROSCIENCE

    1. Top of page
    2. REVIEW
    3. DEVELOPMENTAL NEUROSCIENCE
    4. BEHAVIORAL NEUROSCIENCE
    5. COGNITIVE NEUROSCIENCE
    1. Brain responses to audiovisual speech mismatch in infants are associated with individual differences in looking behaviour (pages 3363–3369)

      Elena Kushnerenko, Przemyslaw Tomalski, Haiko Ballieux, Helena Ribeiro, Anita Potton, Emma L. Axelsson, Elizabeth Murphy and Derek G. Moore

      Article first published online: 28 JUL 2013 | DOI: 10.1111/ejn.12317

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      The present study demonstrates the importance of combining electrophysiological (high-density ERPs) and behavioural (eye-tracking) measures in infancy research. The results have significant implications for understanding differences in brain responses rates of maturation in infants, demonstrating that individual differences in neural signatures of audiovisual integration are related to the behavioural level of maturity of audiovisual processing rather than to chronological age.

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      Bihemispheric stimulation over left and right inferior frontal region enhances recovery from apraxia of speech in chronic aphasia (pages 3370–3377)

      Paola Marangolo, Valentina Fiori, Susanna Cipollari, Serena Campana, Carmelina Razzano, Margherita Di Paola, Giacomo Koch and Carlo Caltagirone

      Article first published online: 11 AUG 2013 | DOI: 10.1111/ejn.12332

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      Eight aphasics with apraxia of speech underwent an intensive language therapy with concomitant anodal, ipsilesional stimulation and cathodal, contralesional stimulation over the left and right inferior frontal gyrus. After 2 weeks, a significant improvement in terms of better accuracy and speed in articulating the treated stimuli and in other nontreated language domains was found for real stimulation compared to the sham condition. Bihemispheric stimulation may be considered an useful tool to speed up the recovery process in chronic aphasia.

    3. The influence of dopamine-related genes on perceptual stability (pages 3378–3383)

      Katharina Schmack, Maria Sekutowicz, Hannes Rössler, Eva J. Brandl, Daniel J. Müller and Philipp Sterzer

      Article first published online: 22 AUG 2013 | DOI: 10.1111/ejn.12339

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      Here, we present evidence that genetic differences in dopaminergic neurotransmission might provide the neurobiological link between bipolar disorder and slowed bistable perception. Using an endophenotype approach we find that the bipolar disorder risk allele of the functional VNTR polymorphism in the dopamine receptor D4 gene (DRD4-2R) is associated with slowed perceptual switching during bistable perception in healthy human participants.

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