Involvement of astroglial glutamate–glutamine shuttle in modulation of the jaw-opening reflex following infraorbital nerve injury (pages 2050–2059)
Rahman Md. Mostafeezur, Masamichi Shinoda, Syunpei Unno, Hossain Md. Zakir, Hanako Takatsuji, Kojiro Takahashi, Yoshiaki Yamada, Kensuke Yamamura, Koichi Iwata and Junichi Kitagawa
Article first published online: 25 MAR 2014 | DOI: 10.1111/ejn.12562
To evaluate the mechanisms underlying orofacial motor dysfunction associated with trigeminal nerve injury, we studied the astroglial cell activation following chronic constriction injury (CCI) of the infraorbital nerve (ION) immunohistochemically, nocifensive behavior in ION-CCI rats and the effect of glutamine synthase (GS) blocker methionine sulfoximine (MSO) on jaw-opening reflex (JOR), and also studied if glutamate-glutamine shuttle mechanism is involved in orofacial motor dysfunction. GFAP immunoreactive cells were observed in the trigeminal motor nucleus (motV) 3 and 14 days after ION-CCI, and the nocifensive behavior and JOR amplitude were also strongly enhanced at these days after ION-CCI.