Widespread microRNA dysregulation in multiple system atrophy – disease-related alteration in miR-96 (pages 1026–1041)
Kiren Ubhi, Edward Rockenstein, Christine Kragh, Chandra Inglis, Brian Spencer, Sarah Michael, Michael Mante, Anthony Adame, Douglas Galasko and Eliezer Masliah
Version of Record online: 5 DEC 2013 | DOI: 10.1111/ejn.12444
There is widespread miRNA dysregulation in mouse models of neurodegenerative disorders. Analysis of miRNA profiles may help identify disease-specific and/or disease-common patterns of miRNA dysregulation. miRNA dysregulation in murine models of multiple system atrophy recapitulate the human profile. Dysregulation of miR-96 and its target genes may play a role in multiple system atrophy.