Transcranial brain sonography findings in two main variants of progressive supranuclear palsy
Article first published online: 23 NOV 2012
© 2012 The Author(s) European Journal of Neurology © 2012 EFNS
European Journal of Neurology
Volume 20, Issue 3, pages 552–557, March 2013
How to Cite
Kostić, V. S., Mijajlović, M., Smajlović, D., Lukić, M. J., Tomić, A. and Svetel, M. (2013), Transcranial brain sonography findings in two main variants of progressive supranuclear palsy. European Journal of Neurology, 20: 552–557. doi: 10.1111/ene.12034
- Issue published online: 14 FEB 2013
- Article first published online: 23 NOV 2012
- Manuscript Accepted: 10 OCT 2012
- Manuscript Received: 24 APR 2012
- Ministry of Science and Technology of the Republic of Serbia. Grant Number: 175090
- progressive supranuclear palsy;
- transcranial sonography
Background and purpose
Progressive supranuclear palsy (PSP) can occur with two main clinical presentations, classified as classical Richardson's syndrome (PSP-RS) and as PSP-parkinsonism (PSP-P), the most common atypical PSP variant. The differential diagnosis between them is challenging. Therefore, we studied different ultrasound markers by transcranial sonography in individuals with PSP-RS and PSP-P, to test their value in the diagnostic work up of these patients.
Transcranial sonography was performed in 21 patients with PSP-RS and 11 patients with PSP-P. Echogenic sizes of the substantia nigra (SN) and the lenticular nuclei (LN), as well as the width of the third ventricle, were measured.
Among the patients with PSP-RS and PSP-P, three (14%) and eight (73%) patients had a hyperechogenic SN (P = 0.020), respectively. Uni- or bilateral hyperechogenicity of the LN was observed in 67% and 36% of patients with PSP-RS and PSP-P, respectively (P = 0.101). Third ventricle was significantly wider in patients with PSP-RS (11.2 ± 2.3 mm) when compared with patients with PSP-P (7.5 ± 1.4 mm; P = 0.001).
Our data, possibly reflecting pathological differences, primarily contribute supporting the view that the neurodegenerative process differs in the two PSP variants.