ene12036-sup-0001-VideoS1.wmvvideo/wmv2715KVideo S1. (a) Segment 1 (severe RLS – pre-treatment). After being exposed to promethazine and diphenhydramine, the patient displays uncontrolled large-amplitude movements of legs while lying in bed accompanied by an uncomfortable sensation mostly in the legs. Some truncal twisting movements and minimal movements in the left upper extremity are also seen. (b) Segment 2 (post-treatment). The patient is able to lie completely still after treatment with i.v. morphine. She also reports that the uncomfortable sensations in her legs have significantly improved although they have not completely resolved.

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