Prestroke antiplatelet therapy and early prognosis in stroke patients: the Dijon Stroke Registry

Authors

  • Y. Béjot,

    Corresponding author
    • Dijon Stroke Registry, Department of Neurology, University Hospital and Medical School of Dijon, University of Burgundy, Dijon, France
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  • C. Aboa-Eboulé,

    1. Dijon Stroke Registry, Department of Neurology, University Hospital and Medical School of Dijon, University of Burgundy, Dijon, France
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  • E. de Maistre,

    1. Department of Biological Hematology, University Hospital of Dijon, Dijon, France
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  • A. Jacquin,

    1. Dijon Stroke Registry, Department of Neurology, University Hospital and Medical School of Dijon, University of Burgundy, Dijon, France
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  • O. Troisgros,

    1. Dijon Stroke Registry, Department of Neurology, University Hospital and Medical School of Dijon, University of Burgundy, Dijon, France
    2. Department of Rehabilitation, University Hospital of Dijon, Dijon, France
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  • M. Hervieu,

    1. Dijon Stroke Registry, Department of Neurology, University Hospital and Medical School of Dijon, University of Burgundy, Dijon, France
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  • G. V. Osseby,

    1. Dijon Stroke Registry, Department of Neurology, University Hospital and Medical School of Dijon, University of Burgundy, Dijon, France
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  • O. Rouaud,

    1. Dijon Stroke Registry, Department of Neurology, University Hospital and Medical School of Dijon, University of Burgundy, Dijon, France
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  • M. Giroud

    1. Dijon Stroke Registry, Department of Neurology, University Hospital and Medical School of Dijon, University of Burgundy, Dijon, France
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Correspondence: Y. Bejot, Dijon Stroke Registry, Department of Neurology, CHU, 3 Rue du Faubourg Raines, 21000 Dijon, France

(tel.: +33 380 293753; fax: +33 380 293672; e-mail: ybejot@yahoo.fr).

Abstract

Background and purpose

Previous antiplatelet therapy (APT) in cardiovascular prevention is common in patients with first-ever stroke. We aimed to evaluate the prognostic value of APT on early outcome in stroke patients.

Methods

All first-ever strokes from 1985 to 2011 were identified from the population-based Stroke Registry of Dijon, France. Demographic features, risk factors, prestroke treatments and clinical information were recorded. Multivariate analyses were performed to evaluate the associations between pre-admission APT and both severe handicap at discharge, and mortality at 1 month and 1 year.

Results

Among the 4275 patients, 870 (20.4%) were previously treated with APT. Severe handicap at discharge was noted in 233 (26.8%) APT users and in 974 (28.7%) non-users. Prestroke APT use was associated with lower odds of severe handicap at discharge [adjusted odds ratio (OR): 0.79; 95% confidence interval (CI): 063–1.00; P = 0.046], non-significant better survival at 1 month [adjusted hazard ratio (HR): 0.87; 95% CI: 0.70–1.09; P = 0.222] and no effect on 1-year mortality (HR: 0.94; 95% CI 0.80–1.10; P = 0.429). In stratum-specific analyses, APT was associated with a lower risk of 1-month mortality in patients with cardioembolic ischaemic stroke (HR: 0.65; 95% CI: 0.43–0.98; P = 0.040).

Conclusions

APT before stroke was associated with less severe handicap at discharge, with no significant protective effect for mortality at 1 month except in patients with cardioembolic stroke. No protective effect of APT was observed for mortality at 1 year. Further studies are needed to understand the mechanisms underlying the distinct effects of prior APT observed across the ischaemic stroke subtypes.

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