Do systolic BP and pulse pressure relate to ventricular enlargement?
Version of Record online: 7 JAN 2013
© 2013 The Author(s) European Journal of Neurology © 2013 EFNS
European Journal of Neurology
Volume 20, Issue 4, pages 720–724, April 2013
How to Cite
Graff-Radford, N. R., Knopman, D. S., Penman, A. D., Coker, L. H. and Mosley, T. H. (2013), Do systolic BP and pulse pressure relate to ventricular enlargement?. European Journal of Neurology, 20: 720–724. doi: 10.1111/ene.12067
- Issue online: 12 MAR 2013
- Version of Record online: 7 JAN 2013
- Manuscript Accepted: 7 NOV 2012
- Manuscript Received: 3 AUG 2012
- pulse pressure;
- systolic blood pressure
Background and purpose
To evaluate the association between systolic, diastolic and pulse pressure, and increase in ventricular size (VS). Observations in laboratory animals suggest intraventricular pulse pressure (systolic–diastolic) may play a role in ventricular enlargement.
Initial magnetic resonance (MR) scans and vascular risk factors evaluation were performed in 1812 Atherosclerosis Risk in Communities participants in 1994–1995. In 2004–2006, 1130 participants underwent repeat MR. VS was rated using a validated nine-point scale. Multiple logistic regression analysis assessed association between blood pressure measures and pulse pressure, and the change between the MR scans of VS controlling for age, sex and race.
At baseline 1112 participants (385 black women, 200 black men, 304 white women and 223 white men) had a mean age of 61.7 ± 4.3 years. In adjusted models pulse pressure at baseline was associated with an increase in VS [odds ratio (OR) 1.19, 95% confidence interval (CI) 1.01–1.40], as was systolic pressure (OR 1.28, 95% CI 1.03–1.58).
Systolic pressure and pulse pressure are associated with future development of increased VS. The findings are consistent with the animal literature that increased pulse pressure predisposes to risk of future increased VS. High pulse pressure might play a role in the pathogenesis of normal pressure hydrocephalus.