The evoked potentials score improves the identification of benign MS without cognitive impairment


Correspondence: L. Pugnetti, Laboratory of Clinical Neurophysiology, Scientific Institute (IRCCS) S. Maria Nascente, don C. Gnocchi Foundation, Via Capecelatro 66, 20148 Milan, Italy (tel.: +390240308356; fax: +390240308290; e-mail:


Background and purpose

The presence of cognitive impairments (CI) among Benign MS (BMS) patients has challenged actual BMS criteria. We hypothesized that a low evoked potentials score (EP-score) at first neurological evaluation would help identify BMS patients without CI.


The EP-score was retrospectively computed in 29 putative BMS patients who were then tested for CI during 2012. The difference in the prevalence of CI between low EP-score patients and the recent literature was assessed using resampling methods.


Among 23 low EP-score patients, only 3 (13%) had CI. This percentage was significantly reduced (P-values 0.05–0.005) compared to recent literature (39–46%).


We conclude that a low EP-score at first neurological evaluation successfully helps to identify BMS patients without CI.