The evoked potentials score improves the identification of benign MS without cognitive impairment
Article first published online: 7 JAN 2013
© 2013 Scientific Institute S. Maria Nascente, Don C. Gnocchi Foundation European Journal of Neurology © 2013 EFNS
European Journal of Neurology
Volume 20, Issue 10, pages 1423–1425, October 2013
How to Cite
Margaritella, N., Mendozzi, L., Tronci, F., Colicino, E., Garegnani, M., Nemni, R., Gilardi, E. and Pugnetti, L. (2013), The evoked potentials score improves the identification of benign MS without cognitive impairment. European Journal of Neurology, 20: 1423–1425. doi: 10.1111/ene.12071
- Issue published online: 12 SEP 2013
- Article first published online: 7 JAN 2013
- Manuscript Accepted: 7 NOV 2012
- Manuscript Received: 10 SEP 2012
- Italian Ministry of Health
- Ricerca Corrente funding program. Grant Number: RC2011
- benign MS;
- evoked potentials;
- evoked potentials score;
- multiple sclerosis;
- resampling methods
Background and purpose
The presence of cognitive impairments (CI) among Benign MS (BMS) patients has challenged actual BMS criteria. We hypothesized that a low evoked potentials score (EP-score) at first neurological evaluation would help identify BMS patients without CI.
The EP-score was retrospectively computed in 29 putative BMS patients who were then tested for CI during 2012. The difference in the prevalence of CI between low EP-score patients and the recent literature was assessed using resampling methods.
Among 23 low EP-score patients, only 3 (13%) had CI. This percentage was significantly reduced (P-values 0.05–0.005) compared to recent literature (39–46%).
We conclude that a low EP-score at first neurological evaluation successfully helps to identify BMS patients without CI.