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Keywords:

  • benign MS;
  • cognition;
  • evoked potentials;
  • evoked potentials score;
  • multiple sclerosis;
  • resampling methods

Background and purpose

The presence of cognitive impairments (CI) among Benign MS (BMS) patients has challenged actual BMS criteria. We hypothesized that a low evoked potentials score (EP-score) at first neurological evaluation would help identify BMS patients without CI.

Methods

The EP-score was retrospectively computed in 29 putative BMS patients who were then tested for CI during 2012. The difference in the prevalence of CI between low EP-score patients and the recent literature was assessed using resampling methods.

Results

Among 23 low EP-score patients, only 3 (13%) had CI. This percentage was significantly reduced (P-values 0.05–0.005) compared to recent literature (39–46%).

Conclusion

We conclude that a low EP-score at first neurological evaluation successfully helps to identify BMS patients without CI.