Optical coherence tomography does not support optic nerve involvement in amyotrophic lateral sclerosis
Article first published online: 14 APR 2013
© 2013 The Author(s) European Journal of Neurology © 2013 EFNS
European Journal of Neurology
Volume 20, Issue 8, pages 1170–1176, August 2013
How to Cite
Roth, N. M., Saidha, S., Zimmermann, H., Brandt, A. U., Oberwahrenbrock, T., Maragakis, N. J., Tumani, H., Ludolph, A. C., Meyer, T., Calabresi, P. A. and Paul, F. (2013), Optical coherence tomography does not support optic nerve involvement in amyotrophic lateral sclerosis. European Journal of Neurology, 20: 1170–1176. doi: 10.1111/ene.12146
- Issue published online: 5 JUL 2013
- Article first published online: 14 APR 2013
- Manuscript Accepted: 14 FEB 2013
- Manuscript Received: 21 AUG 2012
- German Research Foundation. Grant Number: DFG Exc 257
- amyotrophic lateral sclerosis;
- multisystem disorder;
- optical coherence tomography;
Background and purpose
In recent years a possible non-motor involvement of the nervous system in amyotrophic lateral sclerosis (ALS) has come into the focus of research and has been investigated by numerous techniques. Optical coherence tomography (OCT) – with its potential to reveal neuroaxonal retinal damage – may be an appropriate tool to investigate whether the anterior visual pathway is involved. Our aim was to determine whether OCT-based measures of retinal nerve fiber layer, ganglion cell layer, inner nuclear layer and outer nuclear layer thickness are abnormal in ALS, or correlated with disease severity.
Seventy-six ALS patients (144 eyes) and 54 healthy controls (108 eyes; HCs) were examined with OCT, including automated intraretinal macular segmentation. ALS disease severity was determined with the Amyotrophic Lateral Sclerosis Functional Rating Scale – Revised.
There was no significant difference between ALS patients and HCs in any of the examined OCT measures. Moreover, OCT parameters showed no correlation with clinical measures of disease severity.
These findings indicate that involvement of the anterior visual pathway is not one of the non-motor manifestations of ALS.