Cholesterol affects retinal nerve fiber layer thickness in patients with multiple sclerosis with optic neuritis
Article first published online: 14 APR 2013
© 2013 The Author(s) European Journal of Neurology © 2013 EFNS
European Journal of Neurology
Volume 20, Issue 9, pages 1264–1271, September 2013
How to Cite
Kardys, A., Weinstock-Guttman, B., Dillon, M., Masud, M. W., Weinstock, N., Mahfooz, N., Lang, J. K., Weinstock, A., Lincoff, N., Zivadinov, R. and Ramanathan, M. (2013), Cholesterol affects retinal nerve fiber layer thickness in patients with multiple sclerosis with optic neuritis. European Journal of Neurology, 20: 1264–1271. doi: 10.1111/ene.12162
- Issue published online: 29 JUL 2013
- Article first published online: 14 APR 2013
- Manuscript Accepted: 28 FEB 2013
- Manuscript Received: 27 OCT 2012
- National Multiple Sclerosis Society. Grant Number: RG3743
- Pediatric MS Center of Excellence Center
- Department of Defense Multiple Sclerosis Program. Grant Number: MS090122
- environment factors;
- multiple sclerosis;
- optic neuritis;
Background and purpose
To evaluate the associations between retinal nerve fiber layer (RNFL) thickness and lipid profiles in multiple sclerosis (MS).
This study enrolled 136 patients with MS (n = 272 eyes; 108 females, 28 males, mean age: 46.7 ± 8.9 years); 45% had a history of optic neuritis (ON). Subjects received optical coherence tomography (OCT) testing to assess RNFL thickness and visual acuity testing with Snellen charts. A subset of 88 patients received pattern reversal visual-evoked potential (PRVEP) testing. Lipid profiles consisting of serum high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol and total cholesterol (TC) levels were obtained within ± 6 months of OCT. Regression analyses were used to assess the associations between RNFL thickness and lipid profile variables.
Low RNFL thickness (P = 0.008) and higher PRVEP latency (P = 0.017) were associated with high LDL cholesterol > 100 mg/dl status. Low RNFL thickness (P = 0.008) and higher PRVEP latency (P = 0.043) were associated with high HDL cholesterol levels. Low RNFL thickness was also associated with HDL cholesterol > 60 mg/dl status (P = 0.001) and with TC > 200 mg/dl status (P = 0.015). The probability of average RNFL thickness in the lowest tertile (≤ 33rd percentile) was associated with interactions between TC > 200 mg/dl status (P = 0.001, odds ratio = 7.5, 95% confidence interval = 2.7–21) with affected/unaffected by ON status.
High cholesterol adversely affects RNFL thickness in patients with MS with ON.