Epidemiology of chronic inflammatory neuropathies in southeast England
Version of Record online: 17 MAY 2013
© 2013 The Author(s) European Journal of Neurology © 2013 EFNS
European Journal of Neurology
Volume 21, Issue 1, pages 28–33, January 2014
How to Cite
Mahdi-Rogers, M. and Hughes, R. A. C. (2014), Epidemiology of chronic inflammatory neuropathies in southeast England. European Journal of Neurology, 21: 28–33. doi: 10.1111/ene.12190
- Issue online: 10 DEC 2013
- Version of Record online: 17 MAY 2013
- Manuscript Accepted: 8 APR 2013
- Manuscript Received: 28 JAN 2013
- GBS/CIDP Foundation International
- chronic inflammatory demyelinating polyradiculoneuropathy;
- multifocal motor neuropathy;
- paraproteinaemic demyelinating neuropathy
Background and purpose
There is little information about the prevalence and disease burden of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy (MMN) and paraproteinaemic demyelinating neuropathy (PDN).
Multiple sources were used to study the prevalence and clinical features of these diseases in a southeast England population of 3 557 352 people.
The crude prevalences were as follows: CIDP, 2.84 (95% CI 2.31–3.45); MMN, 0.53 (95% CI 0.32–0.83); and PDN, 1.04 (95% CI 0.73–1.43) per 100 000 population. All three diseases were more common in men than in women. The peak decade of onset was older in those with CIDP (70–79 years) and PDN (70–79 years) than in those with MMN (50–59 years). Disability was greater in CIDP and PDN, with median (range) overall neuropathy limitations scores of 4 (0–8) and 4 (1–6), respectively, than in MMN, with a score of 2 (1–5).
The common forms of chronic inflammatory neuropathy cause a considerable disease burden in the community.