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Keywords:

  • chronic inflammatory demyelinating polyradiculoneuropathy;
  • disability;
  • epidemiology;
  • multifocal motor neuropathy;
  • paraproteinaemic demyelinating neuropathy

Background and purpose

There is little information about the prevalence and disease burden of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy (MMN) and paraproteinaemic demyelinating neuropathy (PDN).

Methods

Multiple sources were used to study the prevalence and clinical features of these diseases in a southeast England population of 3 557 352 people.

Results

The crude prevalences were as follows: CIDP, 2.84 (95% CI 2.31–3.45); MMN, 0.53 (95% CI 0.32–0.83); and PDN, 1.04 (95% CI 0.73–1.43) per 100 000 population. All three diseases were more common in men than in women. The peak decade of onset was older in those with CIDP (70–79 years) and PDN (70–79 years) than in those with MMN (50–59 years). Disability was greater in CIDP and PDN, with median (range) overall neuropathy limitations scores of 4 (0–8) and 4 (1–6), respectively, than in MMN, with a score of 2 (1–5).

Conclusion

The common forms of chronic inflammatory neuropathy cause a considerable disease burden in the community.