Benefits of treatment with rasagiline for fatigue symptoms in patients with early Parkinson's disease
Version of Record online: 21 JUN 2013
© 2013 The Author(s) European Journal of Neurology © 2013 EFNS
European Journal of Neurology
Volume 21, Issue 2, pages 357–360, February 2014
How to Cite
Stocchi, F. and The ADAGIO investigators (2014), Benefits of treatment with rasagiline for fatigue symptoms in patients with early Parkinson's disease. European Journal of Neurology, 21: 357–360. doi: 10.1111/ene.12205
- Issue online: 13 JAN 2014
- Version of Record online: 21 JUN 2013
- Manuscript Accepted: 30 APR 2013
- Manuscript Received: 26 JAN 2013
- Parkinson's disease;
Background and purpose
Fatigue is a common symptom of Parkinson's disease (PD), often considered by patients as one of the most disabling PD symptoms with significant impact on quality of life. Our aim was to assess the benefits of rasagiline treatment on fatigue in early PD patients.
In this sub-study of ADAGIO (N Engl J Med 2009; 361: 1268), 1105 untreated PD patients were randomized to receive rasagiline 1 mg/day (n = 270) or 2 mg/day (n = 277) or placebo (n = 558) for 36 weeks. The 16-item Parkinson Fatigue Scale (PFS) was assessed at baseline and at week 36/early withdrawal visit. Changes from baseline to last observed visit for each rasagiline group were compared with placebo using ancova.
Mean baseline PFS score was 2.2 ± 0.9 units. At 36 weeks, patients receiving placebo showed greater progression of symptoms (0.17 units) from baseline in PFS scores compared with the 1 mg/day (0.03 units) and 2 mg/day rasagiline groups (−0.02 units); the difference versus placebo was significant for both rasagiline groups (P < 0.01).
Symptoms of fatigue can be detected in patients with early PD and progressively worsen over time. Rasagiline was associated with significantly less progression of fatigue compared with placebo over a 9-month period.