These authors contributed equally to this work.
Toll-like receptor-9 in Spanish multiple sclerosis patients: an association with the gender
Article first published online: 4 JUN 2013
© 2013 The Author(s) European Journal of Neurology © 2013 EFNS
European Journal of Neurology
Volume 21, Issue 3, pages 537–540, March 2014
How to Cite
Dominguez-Mozo, M. I., Garcia-Montojo, M., López-Cavanillas, M., De Las Heras, V., Garcia-Martinez, A., Arias-Leal, A. M., Casanova, I., Urcelay, E., Arroyo, R. and Alvarez-Lafuente, R. (2014), Toll-like receptor-9 in Spanish multiple sclerosis patients: an association with the gender. European Journal of Neurology, 21: 537–540. doi: 10.1111/ene.12209
- Issue published online: 12 FEB 2014
- Article first published online: 4 JUN 2013
- Manuscript Accepted: 30 APR 2013
- Manuscript Received: 9 OCT 2012
- Instituto de Salud Carlos III-Fondo Europeo de Desarrollo Regional (Feder). Grant Number: 09/02074
- ‘Fundación Mutua Madrileña
- ‘Fundación LAIR
- multiple sclerosis;
Background and purpose
Toll-like receptor-9 (TLR9) is a potent inducer of innate immune system triggered by infection with viruses, some of them previously related to multiple sclerosis (MS). The aim of this study was to analyze the possible association of two TLR9 single nucleotide polymorphisms (SNPs; rs352162 and rs187084) with susceptibility to MS.
Two independent cohorts of MS patients and controls were included: 574 clinically definite relapsing-remitting MS patients (367 females) and 807 healthy controls (418 females) for the first cohort; and 366 relapsing-remitting MS patients (238 females) and 224 healthy controls (160 females) for the second cohort. Genotyping was performed by TaqMan assays.
The AT haplotype was found to be significantly higher in women than in men (P = 0.013 and P = 0.044).
Here two possible genetic markers are proposed that could be also associated with the differences observed in the clinical course of MS in both genders. Further studies with larger cohorts should be performed to confirm these results.