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Migraine is associated with a higher risk of transient global amnesia: a nationwide cohort study

Authors

  • K.-H. Lin,

    1. Department of Medicine, Taipei Veterans General Hospital, Taoyuan Branch, Taoyuan, Taiwan
    2. School of Medicine, National Yang-Ming University, Taipei, Taiwan
    3. Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
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    • These authors contributed equally to the paper.
  • Y.-T. Chen,

    1. School of Medicine, National Yang-Ming University, Taipei, Taiwan
    2. Department of Medicine, Taipei City Hospital Heping Fuyou Branch, Taipei, Taiwan
    3. Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
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    • These authors contributed equally to the paper.
  • J.-L. Fuh,

    1. School of Medicine, National Yang-Ming University, Taipei, Taiwan
    2. Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    3. Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan
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  • S.-Y. Li,

    1. Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    2. Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
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  • T.-J. Chen,

    1. School of Medicine, National Yang-Ming University, Taipei, Taiwan
    2. Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
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  • C.-H. Tang,

    1. School of Health Care Administration, Taipei Medical University, Taipei, Taiwan
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  • S.-J. Wang

    Corresponding author
    1. School of Medicine, National Yang-Ming University, Taipei, Taiwan
    2. Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    3. Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan
    • Correspondence: Shuu-Jiun Wang, Neurological Institute, Taipei Veterans General Hospital, Taipei 112, Taiwan (tel.: +886 2 28762522; fax: +886 2 28765215; e-mail: sjwang@vghtpe.gov.tw).

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Abstract

Background and purpose

The association between migraine and transient global amnesia (TGA) is not determined. Only two clinic-based studies showed that TGA patients had a higher frequency of migraine history. Our population-based study aimed to investigate whether migraine patients were associated with a higher risk of developing TGA.

Methods

Patients with migraine aged ≥18 years were identified from the Taiwan National Health Insurance Research Database between 2005 and 2009. Each migraine patient was randomly matched to one subject without migraine or other headache disorders based on age, sex and cardiovascular comorbidities. Patients with antecedent stroke, epilepsy or TGA were excluded. Both cohorts were followed up until the end of 2010. The incidence rates of TGA were compared and risk factors were identified.

Results

A total of 158 301 patients in the migraine cohort and 158 301 patients in the matched control cohort were enrolled. During a mean follow-up of 3.0 years (range 0–6 years), the migraine cohort had a greater risk of developing TGA than the control cohort [7.59 vs. 3.06 per 100 000 person-years, incidence rate ratio (IRR) = 2.48, P = 0.002]. Compared with the matched cohort, only female migraine patients aged 40–60 years showed a significantly higher risk of TGA [IRR = 3.18 (1.31–8.82), P = 0.005]. Of note, the incidence rates did not differ between migraine patients with and without aura.

Conclusions

This population-based study demonstrates that migraine is associated with an increased risk of TGA, particularly in female patients aged 40–60 years.

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