MoCA-assessed cognitive function and excellent outcome after aneurysmal subarachnoid hemorrhage at 1 year
Version of Record online: 28 JAN 2014
© 2014 The Author(s) European Journal of Neurology © 2014 EFNS
European Journal of Neurology
Volume 21, Issue 5, pages 725–730, May 2014
How to Cite
Wong, G. K. C., Lam, S. W., Wong, A., Lai, M., Siu, D., Poon, W. S. and Mok, V. (2014), MoCA-assessed cognitive function and excellent outcome after aneurysmal subarachnoid hemorrhage at 1 year. European Journal of Neurology, 21: 725–730. doi: 10.1111/ene.12363
- Issue online: 9 APR 2014
- Version of Record online: 28 JAN 2014
- Manuscript Accepted: 17 DEC 2013
- Manuscript Received: 4 SEP 2013
- Neurosurgery Research and Training Fund
- Chinese University of Hong Kong
- cerebral aneurysm;
- Mini-Mental State Examination;
- Montreal Cognitive Assessment;
- subarachnoid hemorrhage
Background and purpose
After aneurysmal subarachnoid hemorrhage (aSAH), cognitive impairment, even mild and relatively isolated, can be devastating, especially in working-age persons. The Montreal Cognitive Assessment (MoCA) is accepted as a valid screening tool for mild cognitive impairment due to cerebral ischaemia. Whether MoCA is independently associated with excellent outcome [a score of 0 on the modified Rankin Scale (mRS) or 18/18 on the Lawton Instrumental Activities of Daily Living (IADL) scale] 1 year after aSAH was assessed.
Hong Kong Chinese aSAH patients were assessed prospectively by means of the MoCA, Mini-Mental State Examination (MMSE), mRS and IADL scale at 1 year. This multicenter prospective observational study is registered at ClinicalTrials.gov of the US National Institutes of Health (NCT01038193).
In all, 194 patients completed the assessments at 1 year. After adjustment for age, both excellent IADL and mRS outcomes were associated with MoCA (OR 1.2, 95% CI 1.1–1.3, P < 0.001, and OR 1.1, 95% CI 1.0–1.2, P = 0.001, respectively).
MoCA-assessed cognitive function is an important determinant for excellent outcomes after aSAH.