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Data S1. [11C]PiB PET imaging.

Data S2. Acquisition of three-dimensional MR images.

Data S3. Measurement of WMH volume and lacunes.

Data S4. Image processing for cortical thickness measurement.

Data S5. Image processing for hippocampal shape and volume measurement.

Table S1. Relationship between the neuropsychological test scores and the mean cortical thickness or mean hippocampal deformity of the areas where there were significant differences between groups.

Figure S1. The MRI findings of each patient with PiB(−) svMCI (a) and PiB(−) SVaD (b). All the patients exhibited significant ischaemia, defined as a cap or band ≥10 mm as well as a deep white matter lesion ≥25 mm.

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